Endeavors in molecular nanosciences are increasingly directed toward structural and dynamic
control of hierarchical self-assembly.[1, 2] These lines of research are often inspired by …

Mammalian tissues engage in specialized physiology that is regulated through reversible
modification of protein cysteine residues by reactive oxygen species (ROS). ROS regulate a …

Cocrystallization is an important method to obtain high-energy and low-sensitivity explosives.
Therefore, the synthesis, structures, and properties of cocrystal energetic materials have …

Targeted protein degradation is a promising drug development paradigm. Here we leverage
this strategy to develop a new class of small molecule antivirals that induce proteasomal …

Targeted protein degradation (TPD) uses small molecules to recruit E3 ubiquitin ligases into
the proximity of proteins of interest, inducing ubiquitination-dependent degradation. A major …

Developing conductive underwater glue for fast sealing and in situ monitoring is critical for
ocean exploration yet remains a challenge. The fluidity of glue is a double‐edged sword that …

An acid–base switchable [c2]daisy chain rotaxane terminated with two 2,6‐diacetylamino
pyridine units has been self‐assembled with a bis(uracil) linker. The complementary hydrogen‐…

Cereblon (CRBN) is an E3 ligase adapter protein that can be reprogrammed by imide-class
compounds such as thalidomide, lenalidomide, and pomalidomide to induce the …

Oral defects lead to a series of function disorders, severely threatening the patients’ health.
Although injectable hydrogels are widely studied in tissue regeneration, their mechanical …

Aberrant activation of FGFR signaling occurs in many cancers, and ATP‐competitive FGFR
inhibitors have received regulatory approval. Despite demonstrating clinical efficacy, these …