In silico drug discovery of major metabolites from spices as SARS-CoV-2 main protease inhibitors

…, AHM Abdelrahman, TA Hussien, EAA Badr… - Computers in Biology …, 2020 - Elsevier
Coronavirus Disease 2019 (COVID-19) is an infectious illness caused by Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), originally identified in Wuhan, China (…

In Silico Targeting Human Multidrug Transporter ABCG2 in Breast Cancer: Database Screening, Molecular Docking, and Molecular Dynamics Study

MAA Ibrahim, EAA Badr, AHM Abdelrahman… - Molecular …, 2022 - Wiley Online Library
ABCG2 is a substantial member of the ABC transporter superfamily that plays a significant
role in multidrug resistance in cancer. Until recently, the 3D structure of ABCG2 has not been …

Naturally occurring plant-based anticancerous candidates as prospective ABCG2 inhibitors: An in silico drug discovery study

MAA Ibrahim, AHM Abdelrahman, EAA Badr… - Molecular Diversity, 2022 - Springer
ATP-binding cassette transporter G2 (ABCG2) is an efflux transporter related to the clinical
multidrug resistance (MDR) phenomenon. Identifying ABCG2 inhibitors could help discover …

Prospective drug candidates as human multidrug transporter ABCG2 inhibitors: An in silico drug discovery study

MAA Ibrahim, EAA Badr, AHM Abdelrahman… - Cell Biochemistry and …, 2021 - Springer
Breast cancer resistance protein (ABCG2) is a human ATP-binding cassette (ABC) that plays
a paramount role in multidrug resistance (MDR) in cancer therapy. The discovery of ABCG2 …

980 Retrospective analysis of prognostic factors of uterine sarcomas:–single institute experience

AA Elzarkaa, MA Elsersy, E Ahmed, EES Badr… - 2024 - ijgc.bmj.com
Introduction/Background Uterine sarcomas are rare aggressive gynecologic malignancies
that are characterized by a high rate of recurrence with poor prognosis. This study aimed to …

Design and evaluation of pyrimidine derivatives as potent inhibitors of ABCG2, a breast cancer resistance protein

S Ahmad, MI Hassan, D Gupta, N Dwivedi, A Islam - 3 Biotech, 2022 - Springer
The protein ATP-binding cassette subfamily G member 2 (ABCG2) is one of the major
factors behind multidrug resistance (MDR) in breast cancer. We performed three-dimensional …

Advancement of structure-activity relationship of multidrug resistance-associated protein 2 interactions

L Xing, Y Hu, Y Lai - The AAPS journal, 2009 - Springer
Multidrug resistance-associated protein 2 (MRP2/ABCC2) is mainly expressed in the apical
phase of barrier membranes. It functions as a critical efflux pump in the biliary excretion of …

An efficient combination of convolutional neural network and LightGBM algorithm for lung cancer histopathology classification

EAR Hamed, MAM Salem, NL Badr, MF Tolba - Diagnostics, 2023 - mdpi.com
The most dangerous disease in recent decades is lung cancer. The most accurate method
of cancer diagnosis, according to research, is through the use of histopathological images …

Egyptian pediatric clinical practice adapted guidelines: evidence-based [2] steroid-resistant nephrotic syndrome (SRNS) 2022

…, D Youssef, M Shouman, S Makar, A Badr… - Egyptian Pediatric …, 2023 - Springer
Background Nephrotic syndrome is one of the most common chronic kidney diseases in
children. Steroid sensitive type (SSNS) constitutes about 85–90%, whereas steroid-resistant …

Assessment of incidence of cerebral vascular diseases and prediction of stroke risk in chronic obstructive pulmonary disease patients using multimodal biomarkers

MY Badr, AA Elkholy, SM Shoeib… - The Clinical …, 2023 - Wiley Online Library
… - Badr - 2023 - … Badr analysed the data and wrote the first draft of the manuscript, and all
co-authors contributed in the critical review of data analysis and manuscript writing. Marwa Badr