Abnormal cardiac ryanodine receptor (RyR2) function is recognized as an important factor
in the pathogenesis of heart failure (HF). However, the specific molecular causes underlying …

The evaluation of the fracture toughness of tungsten is required for the design of plasma-facing
components in order to ensure safe and durable operation in ITER reactor, being under …

Experimental data on partial ordering and α′ precipitation in Fe–Cr alloys and ferritic
steels containing up to 15at.% Cr are summarized. From this data and computer simulations …

MicroRNAs are small endogenous noncoding RNAs that regulate protein expression by
hybridization to imprecise complementary sequences of target mRNAs. Changes in abundance …

Atomic-level simulations are used to investigate the interaction of an edge dislocation with 〈100〉
interstitial dislocation loops in α-iron at 300K. Dislocation reactions are studied …

Calsequestrin is a high-capacity Ca-binding protein expressed inside the sarcoplasmic
reticulum (SR), an intracellular Ca release and storage organelle in muscle. Mutations in the …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial arrhythmogenic
disorder associated with mutations in the cardiac ryanodine receptor (RyR2) and cardiac …

Despite extensive research, the mechanisms responsible for the graded nature and early
termination of Ca 2+ -induced Ca 2+ release (CICR) from the sarcoplasmic reticulum (SR) in …

In this letter, a comprehensive mechanism for the nucleation and growth of bubbles on
dislocations under plasma exposure of tungsten is proposed. The mechanism reconciles long-…

Atomic processes and strengthening effects due to interaction between edge dislocations
and voids in α-iron have been investigated by means of molecular dynamics with a recently …