We have performed a Phase I clinical trial with the naturally occurring flavonoid quercetin (3,3',4',5,7-pentahydroxyflavone).
Quercetin has antiproliferative activity in vitro and is known to …

Background Second-line chemotherapy for patients with oesophagogastric adenocarcinoma
refractory to platinum and fluoropyrimidines has not shown benefits in health-related quality …

Background Evidence is scarce for the effectiveness of therapies for oesophageal cancer
progressing after chemotherapy, and no randomised trials have been reported. We aimed to …

Importance Older and/or frail patients are underrepresented in landmark cancer trials. Tailored
research is needed to address this evidence gap. Objective The GO2 randomized clinical …

Incompressible turbulent flows are investigated in the framework of ideal magnetohydrodynamics.
All the field quantities vary with only two spatial dimensions. Equilibrium canonical …

The equations of motion for turbulent two-dimensional magnetohydrodynamic flows are
solved in the presence of finite viscosity and resistivity, for the case in which external forces (…

Numerical algorithms for surface tension and viscosity are presented in the context of a
Lagrangian treatment of incompressible hydrodynamics with a dynamically restructuring grid. …

Purpose The Cancer Esophagus Gefitinib trial demonstrated improved progression-free
survival with the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib …

PURPOSE To determine the maximum-tolerated dose (MTD) and the dose-limiting toxicities
(DLTs) of a weekly schedule of titanocene dichloride (TD) and to define the …

Continuing work in the design of shock ignition targets is described. Because of reduced
implosion velocity requirements, low target adiabats, and efficient drive by short wavelength …