Background Recent studies indicate an increased frequency of mutations in the gene
encoding glucocerebrosidase (GBA), a deficiency of which causes Gaucher's disease, among …

Alzheimer's disease (AD) is the most common neurodegenerative disorder that affects the
elderly. The increase of lifeexpectancy is transforming AD into a major health-care problem. …

In recent years we have witnessed a major interest in the study of the role of mitochondria,
not only as ATP producers through oxidative phosphorylation but also as regulators of …

Alzheimer's disease (AD) brain reveals high rates of oxygen consumption and oxidative
stress, altered antioxidant defences, increased oxidized polyunsaturated fatty acids, and …

Alzheimer disease (AD) is a neurodegenerative disease which is characterized by the presence
of extracellular senile plaques mainly composed of amyloid-β peptide (Aβ), intracellular …

Alzheimer's disease (AD) is characterized by memory impairment, neurochemically by
accumulation of β-amyloid peptide (namely Aβ 1-42 ) and morphologically by an initial loss of …

Insulin signaling in central nervous system (CNS) has emerged as a novel field of research
since decreased brain insulin levels and/or signaling were associated to impaired learning, …

Cytochrome c oxidase (COX) activity reportedly is reduced in Alzheimer’s disease (AD) brain
and platelets. The reasons for the defect in either tissue are unknown, but its presence in a …

Acetylcholinesterase (AChE) activity is increased within and around amyloid plaques, which
are present in Alzheimer's disease (AD) patient's brain. In this study, using cultured retinal …

Substance abuse and addiction are the most costly of all the neuropsychiatric disorders. In
the last decades, much progress has been achieved in understanding the effects of the drugs …