The transition from transcription initiation to elongation is a key regulatory step in gene
expression, which requires RNA polymerase II (pol II) to escape promoter proximal pausing on …

We describe the discovery of UNC1215, a potent and selective chemical probe for the
methyllysine (Kme) reading function of L3MBTL3, a member of the malignant brain tumor (MBT) …

The mechanisms that underlie and dictate the different biological outcomes of E2F-1 activity
have yet to be elucidated. We describe the residue-specific methylation of E2F-1 by the …

We previously localized a new form of recessive ataxia with generalized tonic-clonic epilepsy
and mental retardation to a 19 Mb interval in 16q21-q23 by homozygosity mapping of a …

Newly emerged SARS-CoV-2 is the cause of an ongoing global pandemic leading to severe
respiratory disease in humans. SARS-CoV-2 targets epithelial cells in the respiratory tract …

In many cells, mRNAs containing inverted repeated Alu elements (IRAlus) in their 3′
untranslated regions (UTRs) are inefficiently exported to the cytoplasm. Such nuclear retention …

MettL3-MettL14 methyltransferase complex has been studied widely for its role in RNA
adenine methylation. This complex is also recruited to UV- and X-ray exposed DNA damaged …

Ebola virus (EBOV) and Marburg virus (MARV) belong to the Filoviridae family and can
cause outbreaks of severe hemorrhagic fever, with high mortality rates in humans. The EBOV …

The euchromatin histone methyltransferase 2 (also known as G9a) methylates histone H3K9
to repress gene expression, but it also acts as a coactivator for some nuclear receptors. The …

Ebola virus (EBOV) is a member of the Filoviridae family and the cause of hemorrhagic
fever outbreaks. The EBOV VP40 (eVP40) matrix protein is the main driving force for virion …