Early tumorigenesis is associated with the engagement of the DNA-damage checkpoint
response (DDR) 1 , 2 . Cell proliferation and transformation induced by oncogene activation are …

Single linear DNA molecules were bound at multiple sites at one extremity to a treated glass
cover slip and at the other to a magnetic bead. The DNA was therefore torsionally …

Chromosomal instability in early cancer stages is caused by stress on DNA replication. The
molecular basis for replication perturbation in this context is currently unknown. We studied …

DNA in amounts representative of hundreds of eukaryotic genomes was extended on silanized
surfaces by dynamic molecular combing. The precise measurement of hybridized DNA …

electrophile-responsive element Page 1 Proc. Natl. Acad. Sci. USA Vol. 87, pp. 6258-6262,
August 1990 Biochemistry Xenobiotic-inducible expression of murine glutathione S-…

Selection of active origins and regulation of interorigin spacing are poorly understood in
mammalian cells. Using tricolor analysis of combed DNA molecules, we studied an amplified …

How eukaryotes specify their replication origins is an important unanswered question. Here,
we analyze the replicative organization of yeast rDNA, which consists of ∼150 identical …

The spatial organization of replicons into clusters is believed to be of critical importance for
genome duplication in higher eukaryotes, but its functional organization still remains to be …

Cdc7 is an essential kinase that promotes DNA replication by activating origins of replication.
Here, we characterized the potent Cdc7 inhibitor PHA-767491 ( 1 ) in biochemical and cell-…

DNA replication initiates at discrete origins along eukaryotic chromosomes. However, in most
organisms, origin firing is not efficient; a specific origin will fire in some but not all cell cycles…