PTEN and the pan phosphoinositide 3-kinase (PI3K) inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1benzopyran-4-one
(LY294002) exert significant control over tumor-induced angiogenesis …

Three GTPases, RAC, RHO, and Cdc42, play essential roles in coordinating many cellular
functions during embryonic development, both in healthy cells and in disease conditions like …

Background Triple Negative subset of (TN) Breast Cancers (BC), a close associate of the
basal-like subtype (with limited discordance) is an aggressive form of the disease which …

Human Epidermal Growth Factor Receptor 2-positive breast cancer (HER2+ BC) is defined
by increased amplification of the ERBB2/neu oncogene and/or overexpression of its …

Breast cancer (BC) is the most common women cancer and second most common cause of
cancer death in women. A woman living in the United States has 12.3% lifetime risk of being …

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is mutated or lost
in 60% to 70% of advanced gliomas and is associated with malignant phenotypic changes …

Mutations of genes in tumor cells of Triple Negative subset of Breast Cancer (TNBC) deregulate
pathways of signal transduction. The loss of tumor suppressor gene PTEN is the most …

The importance and role of the estrogen receptor (ER) pathway have been well-recognized
in both breast cancer development and progression. The treatment of choice in women with …

Phosphoinositide 3-kinase (PI3K) pathway, in addition to its pro-proliferative and antiapoptotic
effects on tumor cells, contributes to DNA damage repair (DDR). We hypothesized that …

Vascular endothelial growth factor (VEGF) dependent tumor angiogenesis is an essential
step for the initiation and promotion of tumor progression. The hypothesis that VEGF-driven …