Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival

MA Hughes, N Harper, M Butterworth, K Cain… - Molecular cell, 2009 - cell.com
The death-inducing signaling complex (DISC) is critical for initiation of death-receptor-mediated
apoptosis; however, paradoxically, CD95 also signals for cell survival. Here, we …

The evaluation of predictive learners: Some theoretical and empirical results

KB Korb, LR Hope, MJ Hughes - … , September 5–7, 2001 Proceedings 12, 2001 - Springer
With the growth of interest in data mining, there has been increasing interest in applying
machine learning algorithms to real-world problems. This raises the question of how to evaluate …

Electrically evoked compound action potential polarity sensitivity, refractory-recovery, and behavioral multi-pulse integration as potential indices of neural health in …

ML Hughes - Hearing research, 2023 - Elsevier
The polarity of an electrical signal can influence the site of spike initiation on auditory
neurons, depending upon the stimulus level, degree of demyelination, and degeneration of …

Co-operative and hierarchical binding of c-FLIP and caspase-8: a unified model defines how c-FLIP isoforms differentially control cell fate

MA Hughes, IR Powley, R Jukes-Jones, S Horn… - Molecular cell, 2016 - cell.com
The death-inducing signaling complex (DISC) initiates death receptor-induced apoptosis.
DISC assembly and activation are controlled by c-FLIP isoforms, which function as pro-…

Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling

N Harper, MA Hughes, SN Farrow, GM Cohen… - Journal of Biological …, 2003 - ASBMB
We have further examined the mechanism by which phorbol ester-mediated protein kinase
C (PKC) activation protects against tumor necrosis factor (TNF)-related apoptosis-inducing …

Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced …

N Harper, M Hughes, M MacFarlane… - Journal of Biological …, 2003 - ASBMB
Death receptors are a subfamily of the tumor necrosis factor (TNF) receptor subfamily. They
are characterized by a death domain (DD) motif within their intracellular domain, which is …

The mass and galaxy distribution around SZ-selected clusters

…, SR Hinton, DL Hollowood, JP Hughes… - Monthly Notices of …, 2021 - academic.oup.com
We present measurements of the radial profiles of the mass and galaxy number density around
Sunyaev–Zel’dovich (SZ)-selected clusters using both weak lensing and galaxy counts. …

Striatal dopaminergic neurons are lost with Parkinson's disease progression

MJ Porritt, AE Kingsbury, AJ Hughes… - … : official journal of the …, 2006 - Wiley Online Library
Increased numbers of dopaminergic neurons are described in the striatum of patients with
Parkinson's disease. In postmortem striatal tissue from Parkinson's disease patients with short …

[BOOK][B] Poets, poetry and new media: Attending to the teaching and learning of poetry

JM Hughes - 2006 - learntechlib.org
This research takes place at the intersection of (1) poetry,(2) digital learning environments,
and (3) multiple literacies, pushing and exploring the boundaries of what can be done with …

One Pre-Service Program's Dispositional Efforts Revealed

MC Hughes - 2014 - digitalcommons.georgefox.edu
… The grandest thank you goes to Team Hughes! First, thank you to the team captain, my …
cheered and cared for Team Hughes the last three years. Team Hughes is honored to share life …