Primary osteoporosis is an age-related disease characterized by an imbalance in bone
homeostasis. While the resorptive aspect of the disease has been studied intensely, less is …

Skeletal development and remodeling of adult bone are critically controlled by activated
NOTCH signaling in genetically modified mice. It is yet unclear whether NOTCH signaling is …

The role of serum amyloid A (SAA) proteins, which are ligands for toll-like receptors, was
analyzed in human bone marrow-derived mesenchymal stem cells (hMSCs) and their …

Heparins are broadly used for the prevention and treatment of thrombosis and embolism.
Yet, osteoporosis is considered to be a severe side effect in up to one third of all patients on …

Osteocytes perceive and process mechanical stimuli in the lacuno-canalicular network in
bone. As a result, they secrete signaling molecules that mediate bone formation and resorption…

Epidermal growth factors (EGFs) eg EGF, heparin-binding EGF and transforming growth
factor alpha and their receptors eg EGFR and ErbB2 control proinflammatory signaling and …

Mesenchymal stem cells play a major role during bone remodelling and are thus of high
interest for tissue engineering and regenerative medicine applications. Mechanical stimuli, that …

The glycosylation of cellular membranes is crucial for the survival and communication of
cells. As our target is the engineering of the glycocalyx, we designed a functionalized lipid …

Dear Editor, Multiple myeloma (MM) is a rarely curable plasma cell malignancy of the bone
marrow (BM) that provides a permissive tumor microenvironment (TME), supporting tumor …

Aseptic loosening of total hip and knee joint replacements is the most common indication for
revision surgery after primary hip and knee arthroplasty. Research suggests that exposure …