User profiles for Mark J. Zylka

Mark J. Zylka

The University of North Carolina at Chapel Hill
Verified email at med.unc.edu
Cited by 16265

Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain

MJ Zylka, LP Shearman, DR Weaver, SM Reppert - Neuron, 1998 - cell.com
We have cloned and characterized the mouse cDNA of a third mammalian homolog of the
Drosophila period gene and designated it mPer3. The mPER3 protein shows ∼37% amino …

[HTML][HTML] Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd

MJ Zylka, FL Rice, DJ Anderson - Neuron, 2005 - cell.com
The brain receives sensory input from diverse peripheral tissues, including the skin, the
body's largest sensory organ. Using genetically encoded axonal tracers expressed from the …

mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop

K Kume, MJ Zylka, S Sriram, LP Shearman, DR Weaver… - Cell, 1999 - cell.com
We determined that two mouse cryptochrome genes, mCry1 and mCry2, act in the negative
limb of the clock feedback loop. In cell lines, mPER proteins (alone or in combination) have …

Topoisomerases facilitate transcription of long genes linked to autism

…, T Magnuson, SJ Chamberlain, BD Philpot, MJ Zylka - Nature, 2013 - nature.com
Topoisomerases are expressed throughout the developing and adult brain and are mutated
in some individuals with autism spectrum disorder (ASD). However, how topoisomerases …

Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine

MJ Zylka, NA Sowa, B Taylor-Blake, MA Twomey… - Neuron, 2008 - cell.com
Thiamine monophosphatase (TMPase, also known as fluoride-resistant acid phosphatase)
is a classic histochemical marker of small-diameter dorsal root ganglia neurons. The …

A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock

X Jin, LP Shearman, DR Weaver, MJ Zylka… - Cell, 1999 - cell.com
We examined the transcriptional regulation of the clock-controlled arginine vasopressin gene
in the suprachiasmatic nuclei (SCN). A core clock mechanism in mouse SCN appears to …

Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei

LP Shearman, MJ Zylka, DR Weaver, LF Kolakowski… - Neuron, 1997 - cell.com
We have characterized a mammalian homolog of the Drosophila period gene and designated
it Per2. The PER2 protein shows >40% amino acid identity to the protein of another …

Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family

MJ Zylka, X Dong, AL Southwell… - Proceedings of the …, 2003 - National Acad Sciences
The Mas-related genes (Mrgs) comprise a family of >50 G protein-coupled receptors (GPCRs),
many of which are expressed in specific subsets of nociceptive sensory neurons in mice. …

[HTML][HTML] Molecular analysis of mammalian timeless

MJ Zylka, LP Shearman, JD Levine, X Jin, DR Weaver… - Neuron, 1998 - cell.com
We cloned the mouse cDNA of a mammalian homolog of the Drosophila timeless (tim) gene
and designated it mTim. The mTim protein shows five homologous regions with Drosophila …

[HTML][HTML] A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons

X Dong, S Han, MJ Zylka, MI Simon, DJ Anderson - Cell, 2001 - cell.com
In vertebrates, peripheral chemosensory neurons express large families of G protein-coupled
receptors (GPCRs), reflecting the diversity and specificity of stimuli they detect. However, …