User profiles for Mark T. Bedford
Mark T. BedfordMD Anderson Cancer Center Verified email at mdanderson.org Cited by 31181 |
Protein arginine methylation in mammals: who, what, and why
MT Bedford, SG Clarke - Molecular cell, 2009 - cell.com
The covalent marking of proteins by methyl group addition to arginine residues can promote
their recognition by binding partners or can modulate their biological activity. A small family …
their recognition by binding partners or can modulate their biological activity. A small family …
Arginine methylation at a glance
MT Bedford - Journal of cell science, 2007 - journals.biologists.com
Arginine methylation is a prevalent post-translational modification found on both nuclear
and cytoplasmic proteins. The methylation of arginine residues is catalyzed by the protein …
and cytoplasmic proteins. The methylation of arginine residues is catalyzed by the protein …
Protein arginine methyltransferases and cancer
Y Yang, MT Bedford - Nature Reviews Cancer, 2013 - nature.com
There are nine protein arginine methyltransferases (PRMTs) encoded in mammalian
genomes, the protein products of which catalyse three types of arginine methylation — …
genomes, the protein products of which catalyse three types of arginine methylation — …
Arginine methylation: an emerging regulatorof protein function
MT Bedford, S Richard - Molecular cell, 2005 - cell.com
Arginine methylation is now coming out of the shadows of protein phosphorylation and
entering the mainstream, largely due to the identification of the family of enzymes that lay down …
entering the mainstream, largely due to the identification of the family of enzymes that lay down …
p53 is regulated by the lysine demethylase LSD1
…, S Opravil, R Shiekhattar, MT Bedford, T Jenuwein… - Nature, 2007 - nature.com
p53, the tumour suppressor and transcriptional activator, is regulated by numerous post-translational
modifications, including lysine methylation 1 , 2 . Histone lysine methylation has …
modifications, including lysine methylation 1 , 2 . Histone lysine methylation has …
Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2)
A Orr-Urtreger, MT Bedford, T Burakova, E Arman… - Developmental …, 1993 - Elsevier
The gene for fibroblast growth factor receptor-2 (FGFR2) encodes two splice variants designated
here as keratinocyte growth factor (KGFR) and bek. Their ligand-binding specificity is …
here as keratinocyte growth factor (KGFR) and bek. Their ligand-binding specificity is …
[HTML][HTML] Histone arginine methylation
A Di Lorenzo, MT Bedford - FEBS letters, 2011 - Elsevier
Arginine methylation is a common posttranslational modification (PTM). This type of PTM
occurs on both nuclear and cytoplasmic proteins, and is particularly abundant on shuttling …
occurs on both nuclear and cytoplasmic proteins, and is particularly abundant on shuttling …
Tudor, MBT and chromo domains gauge the degree of lysine methylation
…, A Lake, M Krishna, L Xia, Y Zhang, MT Bedford - EMBO …, 2006 - embopress.org
The post‐translational modification of histones regulates many cellular processes, including
transcription, replication and DNA repair. A large number of combinations of post‐…
transcription, replication and DNA repair. A large number of combinations of post‐…
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation
…, JC Silva, V Vemulapalli, MT Bedford… - Molecular & Cellular …, 2014 - ASBMB
Protein methylation is a common posttranslational modification that mostly occurs on arginine
and lysine residues. Arginine methylation has been reported to regulate RNA processing, …
and lysine residues. Arginine methylation has been reported to regulate RNA processing, …
Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A
Biological responses to histone methylation critically depend on the faithful readout and
transduction of the methyl-lysine signal by “effector” proteins, yet our understanding of methyl-…
transduction of the methyl-lysine signal by “effector” proteins, yet our understanding of methyl-…