COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …
Spatially organized multicellular immune hubs in human colorectal cancer
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd)
tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors …
tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors …
Multiplex digital spatial profiling of proteins and RNA in fixed tissue
CR Merritt, GT Ong, SE Church, K Barker… - Nature …, 2020 - nature.com
Abstract Digital Spatial Profiling (DSP) is a method for highly multiplex spatial profiling of
proteins or RNAs suitable for use on formalin-fixed, paraffin-embedded (FFPE) samples. The …
proteins or RNAs suitable for use on formalin-fixed, paraffin-embedded (FFPE) samples. The …
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory
cancer. Molecular stratification in pancreatic cancer remains rudimentary and does not yet …
cancer. Molecular stratification in pancreatic cancer remains rudimentary and does not yet …
[HTML][HTML] Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy
Genetically encoded voltage indicators are emerging tools for monitoring voltage dynamics
with cell-type specificity. However, current indicators enable a narrow range of applications …
with cell-type specificity. However, current indicators enable a narrow range of applications …
[HTML][HTML] Three mechanisms assemble central nervous system nodes of Ranvier
Rapid action potential propagation in myelinated axons requires Na+ channel clustering at
nodes of Ranvier. However, the mechanism of clustering at CNS nodes remains poorly …
nodes of Ranvier. However, the mechanism of clustering at CNS nodes remains poorly …
A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier
The scaffolding protein ankyrin-G is required for Na+ channel clustering at axon initial
segments. It is also considered essential for Na+ channel clustering at nodes of Ranvier to …
segments. It is also considered essential for Na+ channel clustering at nodes of Ranvier to …
GeoMx™ RNA assay: high multiplex, digital, spatial analysis of RNA in FFPE tissue
DR Zollinger, SE Lingle, K Sorg, JM Beechem… - In Situ Hybridization …, 2020 - Springer
RNA in situ hybridization (ISH) is a widely used technique for the localization of mRNA in
tissues. Limitations to traditional ISH include the number of targets that can be analyzed …
tissues. Limitations to traditional ISH include the number of targets that can be analyzed …
Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma
L Jerby-Arnon, C Neftel, ME Shore, HR Weisman… - Nature medicine, 2021 - nature.com
Synovial sarcoma (SyS) is an aggressive neoplasm driven by the SS18–SSX fusion, and is
characterized by low T cell infiltration. Here, we studied the cancer–immune interplay in SyS …
characterized by low T cell infiltration. Here, we studied the cancer–immune interplay in SyS …
Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury
BAC Cree, J Niu, KK Hoi, C Zhao, SD Caganap… - Brain, 2018 - academic.oup.com
Hypoxia can injure brain white matter tracts, comprised of axons and myelinating
oligodendrocytes, leading to cerebral palsy in neonates and delayed post-hypoxic …
oligodendrocytes, leading to cerebral palsy in neonates and delayed post-hypoxic …