Interaction between drugs and the gut microbiome
The human gut microbiome is a complex ecosystem that can mediate the interaction of the
human host with their environment. The interaction between gut microbes and commonly …
human host with their environment. The interaction between gut microbes and commonly …
[HTML][HTML] Distinctive inflammatory bowel disease phenotype in primary sclerosing cholangitis
AB de Vries, M Janse, H Blokzijl… - World journal of …, 2015 - ncbi.nlm.nih.gov
AIM: To review the current literature for the specific clinical characteristics of inflammatory
bowel disease (IBD) associated with primary sclerosing cholangitis (PSC). METHODS: A …
bowel disease (IBD) associated with primary sclerosing cholangitis (PSC). METHODS: A …
The influence of proton pump inhibitors and other commonly used medication on the gut microbiota
Proton pump inhibitors (PPIs), used to treat gastro-esophageal reflux and prevent gastric
ulcers, are among the most widely used drugs in the world. The use of PPIs is associated …
ulcers, are among the most widely used drugs in the world. The use of PPIs is associated …
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
We undertook a meta-analysis of six Crohn's disease genome-wide association studies
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up …
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up …
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity
Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-
based cohort shows relations between the microbiome and 126 exogenous and intrinsic …
based cohort shows relations between the microbiome and 126 exogenous and intrinsic …
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Genome-wide association studies and candidate gene studies in ulcerative colitis have
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis …
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis …
Environmental factors shaping the gut microbiome in a Dutch population
The gut microbiome is associated with diverse diseases,–, but a universal signature of a
healthy or unhealthy microbiome has not been identified, and there is a need to understand …
healthy or unhealthy microbiome has not been identified, and there is a need to understand …
Gut microbiome structure and metabolic activity in inflammatory bowel disease
EA Franzosa, A Sirota-Madi, J Avila-Pacheco… - Nature …, 2019 - nature.com
The inflammatory bowel diseases (IBDs), which include Crohn's disease (CD) and ulcerative
colitis (UC), are multifactorial chronic conditions of the gastrointestinal tract. While IBD has …
colitis (UC), are multifactorial chronic conditions of the gastrointestinal tract. While IBD has …