Despite their clear importance as a class of regulatory molecules, pinpointing the relevance
of individual miRNAs has been challenging. Studies querying miRNA functions by …

Background Worldwide, the prevalence of obesity among children has increased
dramatically. Although the etiology of childhood obesity is multifactorial, to date, most …

Summary miR-17∼ 92, miR-106b∼ 25, and miR-106a∼ 363 belong to a family of highly
conserved miRNA clusters. Amplification and overexpression of miR-17∼ 92 is observed in …

The ability to perceive flavors begins in utero with the development and early functioning of
the gustatory and olfactory systems. Because both amniotic fluid and breast milk contain …

Tumorigenesis is a multi-step process that requires activation of oncogenes and inactivation
of tumour suppressor genes. Mouse models of human cancers have recently demonstrated …

We have generated two lentiviral vectors for conditional, Cre-lox-regulated, RNA
interference. One vector allows for conditional activation, whereas the other permits …

Objective: Diagnostic criteria for coeliac disease (CD) from the European Society for
Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) were published in …

Background Celiac disease (CD) is an immune-mediated enteropathic condition triggered in
genetically susceptible individuals by the ingestion of gluten. Although common in Europe …

The acquired immunodeficiency syndrome (AIDS)-causing lentiviruses human
immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) effectively evade …

Secretion of the proinflammatory cytokines, interleukin (IL)-1β and IL-18, usually requires
two signals. The first, due to microbial products such as lipopolysaccharide, initiates …