Neuroinvasion of SARS-CoV-2 in human and mouse brain

E Song, C Zhang, B Israelow, A Lu-Culligan… - Journal of Experimental …, 2021 - rupress.org
Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects
multiple organ systems including the central nervous system (CNS). Yet, there is no …

SARS–CoV-2 infection of the placenta

H Hosier, SF Farhadian, RA Morotti, U Deshmukh… - The Journal of clinical …, 2020 - jci.org
BACKGROUND The effects of the novel coronavirus disease 2019 (COVID-19) in pregnancy
remain relatively unknown. We present a case of second trimester pregnancy with …

Hypothalamic POMC neurons promote cannabinoid-induced feeding

M Koch, L Varela, JG Kim, JD Kim, F Hernández-Nuño… - Nature, 2015 - nature.com
Hypothalamic pro-opiomelanocortin (POMC) neurons promote satiety. Cannabinoid
receptor 1 (CB1R) is critical for the central regulation of food intake. Here we test whether …

[HTML][HTML] Astrocytic insulin signaling couples brain glucose uptake with nutrient availability

C García-Cáceres, C Quarta, L Varela, Y Gao, T Gruber… - Cell, 2016 - cell.com
We report that astrocytic insulin signaling co-regulates hypothalamic glucose sensing and
systemic glucose metabolism. Postnatal ablation of insulin receptors (IRs) in glial fibrillary …

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding

JG Kim, S Suyama, M Koch, S Jin… - Nature …, 2014 - nature.com
We found that leptin receptors were expressed in hypothalamic astrocytes and that their
conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic …

Nucleus reuniens of the midline thalamus: link between the medial prefrontal cortex and the hippocampus

RP Vertes, WB Hoover, K Szigeti-Buck, C Leranth - Brain research bulletin, 2007 - Elsevier
The medial prefrontal cortex and the hippocampus serve well recognized roles in memory
processing. The hippocampus projects densely to, and exerts strong excitatory actions on …

Zika virus disrupts phospho-TBK1 localization and mitosis in human neuroepithelial stem cells and radial glia

M Onorati, Z Li, F Liu, AMM Sousa, N Nakagawa, M Li… - Cell reports, 2016 - cell.com
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other
neurodevelopment defects remain poorly understood. Here, we describe the derivation and …

Vaginal exposure to Zika virus during pregnancy leads to fetal brain infection

LJ Yockey, L Varela, T Rakib, W Khoury-Hanold… - Cell, 2016 - cell.com
Zika virus (ZIKV) can be transmitted sexually between humans. However, it is unknown
whether ZIKV replicates in the vagina and impacts the unborn fetus. Here, we establish a …

Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates

C Leranth, T Hajszan, K Szigeti-Buck, J Bober… - Proceedings of the …, 2008 - pnas.org
Exposure measurements from several countries indicate that humans are routinely exposed
to low levels of bisphenol A (BPA), a synthetic xenoestrogen widely used in the production of …

Intranasal epidermal growth factor treatment rescues neonatal brain injury

J Scafidi, TR Hammond, S Scafidi, J Ritter, B Jablonska… - Nature, 2014 - nature.com
There are no clinically relevant treatments available that improve function in the growing
population of very preterm infants (less than 32 weeks' gestation) with neonatal brain injury …