IL-17 in the immunopathogenesis of spondyloarthritis

LS Taams, KJA Steel, U Srenathan, LA Burns… - Nature reviews …, 2018 - nature.com
Spondyloarthritis (SpA) is a term that refers to a group of inflammatory diseases that includes
psoriatic arthritis, axial SpA and nonradiographic axial SpA, reactive arthritis, enteropathic …

Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans

J Seow, C Graham, B Merrick, S Acors, S Pickering… - Nature …, 2020 - nature.com
Antibody responses to SARS-CoV-2 can be detected in most infected individuals 10–15 d
after the onset of COVID-19 symptoms. However, due to the recent emergence of SARS …

Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis

A Hinks, J Cobb, MC Marion, S Prahalad, M Sudman… - Nature …, 2013 - nature.com
We used the Immunochip array to analyze 2,816 individuals with juvenile idiopathic arthritis
(JIA), comprising the most common subtypes (oligoarticular and rheumatoid factor–negative …

Comparative assessment of multiple COVID-19 serological technologies supports continued evaluation of point-of-care lateral flow assays in hospital and community …

S Pickering, G Betancor, RP Galão, B Merrick… - PLoS …, 2020 - journals.plos.org
There is a clear requirement for an accurate SARS-CoV-2 antibody test, both as a
complement to existing diagnostic capabilities and for determining community …

Psoriatic and rheumatoid arthritis joints differ in the composition of CD8+ tissue-resident memory T cell subsets

GAM Povoleri, LE Durham, EH Gray, S Lalnunhlimi… - Cell reports, 2023 - cell.com
Summary CD69+ CD103+ tissue-resident memory T (T RM) cells are important drivers of
inflammation. To decipher their role in inflammatory arthritis, we apply single-cell, high …

Polyfunctional, proinflammatory, Tissue‐Resident memory phenotype and function of synovial Interleukin‐17A+ CD 8+ T cells in psoriatic arthritis

KJA Steel, U Srenathan, M Ridley… - Arthritis & …, 2020 - Wiley Online Library
Objective Genetic associations imply a role for CD 8+ T cells and the interleukin‐23 (IL‐
23)/IL‐17 axis in psoriatic arthritis (PsA) and other spondyloarthritides (SpA). IL‐17A+ CD …

[HTML][HTML] MicroRNA-155 contributes to enhanced resistance to apoptosis in monocytes from patients with rheumatoid arthritis

M Rajasekhar, AM Olsson, KJA Steel, M Georgouli… - Journal of …, 2017 - Elsevier
Monocytes and macrophages are key mediators of inflammation in rheumatoid arthritis (RA).
Their persistence at the inflammatory site is likely to contribute to immunopathology. We …

Estimates of the rate of infection and asymptomatic COVID-19 disease in a population sample from SE England

PM Wells, KJ Doores, S Couvreur, RM Nunez, J Seow… - Journal of Infection, 2020 - Elsevier
Background Understanding of the true asymptomatic rate of infection of SARS-CoV-2 is
currently limited, as is understanding of the population-based seroprevalence after the first …

Human in vitro-induced IL-17A+ CD8+ T-cells exert pro-inflammatory effects on synovial fibroblasts

EH Gray, U Srenathan, LE Durham… - Clinical and …, 2023 - academic.oup.com
Abstract IL-17A+ CD8+ T-cells, termed Tc17 cells, have been identified at sites of
inflammation in several immune-mediated inflammatory diseases. However, the biological …

Presence, function, and regulation of IL‐17F‐expressing human CD4+ T cells

LA Burns, A Maroof, D Marshall… - European Journal of …, 2020 - Wiley Online Library
The pro‐inflammatory cytokine IL‐17A has been implicated in the immunopathology of
inflammatory arthritis. IL‐17F bears 50% homology to IL‐17A and has recently been …