Positive natural selection is the force that drives the increase in prevalence of advantageous
traits, and it has played a central role in our development as a species. Until recently, the …

The past fifty years have seen the development and application of numerous statistical
methods to identify genomic regions that appear to be shaped by natural selection. These …

The ancient biological'arms race'between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …

Identifying interesting relationships between pairs of variables in large data sets is
increasingly important. Here, we present a measure of dependence for two-variable …

Rapid, inexpensive, and sensitive nucleic acid detection may aid point-of-care pathogen
detection, genotyping, and disease monitoring. The RNA-guided, RNA-targeting clustered …

The ability to detect recent natural selection in the human population would have profound
implications for the study of human history and for medicine. Here, we introduce a framework …

With the advent of dense maps of human genetic variation, it is now possible to detect
positive natural selection across the human genome. Here we report an analysis of over 3 …

With the availability of a dense genome-wide map of single nucleotide polymorphisms
(SNPs), a central issue in human genetics is whether it is now possible to use linkage …

In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra
Leone, and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra …

In most human populations, the ability to digest lactose contained in milk usually disappears
in childhood, but in European-derived populations, lactase activity frequently persists into …