COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …
Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers
During cancer therapy, tumor heterogeneity can drive the evolution of multiple tumor
subclones harboring unique resistance mechanisms in an individual patient,–. Previous …
subclones harboring unique resistance mechanisms in an individual patient,–. Previous …
Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis
MF Thomas, K Slowikowski, K Manakongtreecheep… - Nature medicine, 2024 - nature.com
Immune checkpoint inhibitor (ICI) therapy has revolutionized oncology, but treatments are
limited by immune-related adverse events, including checkpoint inhibitor colitis (irColitis) …
limited by immune-related adverse events, including checkpoint inhibitor colitis (irColitis) …
Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection
The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully
understood. Here we show analysis of autopsy specimens from 24 patients who succumbed …
understood. Here we show analysis of autopsy specimens from 24 patients who succumbed …
PTEN loss mediates clinical cross-resistance to CDK4/6 and PI3Kα inhibitors in breast cancer
C Costa, Y Wang, A Ly, Y Hosono, E Murchie… - Cancer …, 2020 - aacrjournals.org
The combination of CDK4/6 inhibitors with antiestrogen therapies significantly improves
clinical outcomes in ER-positive advanced breast cancer. To identify mechanisms of …
clinical outcomes in ER-positive advanced breast cancer. To identify mechanisms of …
EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion–positive cholangiocarcinoma
FGFR inhibitors are approved for the treatment of advanced cholangiocarcinoma harboring
FGFR2 fusions. However, the response rate is moderate, and resistance emerges rapidly …
FGFR2 fusions. However, the response rate is moderate, and resistance emerges rapidly …
Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer
In patients with metastatic cancer, spatial heterogeneity of somatic alterations may lead to
incomplete assessment of a cancer's mutational profile when analyzing a single tumor …
incomplete assessment of a cancer's mutational profile when analyzing a single tumor …
Biosecurity practices on intensive pig production systems in Chile
CJ Pinto, VS Urcelay - Preventive Veterinary Medicine, 2003 - Elsevier
Chile eradicated classical swine fever (CSF) in April 1998, following a 17-year eradication
programme. The authors describe biosecurity levels of pig farms in Chile after the …
programme. The authors describe biosecurity levels of pig farms in Chile after the …
[HTML][HTML] A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2
The SARS-CoV-2 pandemic has caused over 1 million deaths globally, mostly due to acute
lung injury and acute respiratory distress syndrome, or direct complications resulting in …
lung injury and acute respiratory distress syndrome, or direct complications resulting in …
Immune responses in checkpoint myocarditis across heart, blood and tumour
SM Blum, DA Zlotoff, NP Smith, IJ Kernin, S Ramesh… - Nature, 2024 - nature.com
Immune checkpoint inhibitors are widely used anticancer therapies that can cause morbid
and potentially fatal immune-related adverse events such as immune-related myocarditis …
and potentially fatal immune-related adverse events such as immune-related myocarditis …