User profiles for "author:Perera L"

Lalith Perera

Staff Scientist, National Institute of Environmental Health Sciences
Verified email at niehs.nih.gov
Cited by 31945

New tricks for modelers from the crystallography toolkit: the particle mesh Ewald algorithm and its use in nucleic acid simulations

T Darden, L Perera, L Li, L Pedersen - Structure, 1999 - cell.com
The accurate simulation of DNA and RNA has been a goal of theoretical biophysicists for a
number of years. That is, given a high-resolution experimental structure, or perhaps a …

[HTML][HTML] The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use

PY Perera, JH Lichy, TA Waldmann, LP Perera - Microbes and infection, 2012 - Elsevier
Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in
many diverse cell types. It plays a major role in the development of inflammatory and …

Potential SARS-CoV-2 main protease inhibitors

R Banerjee, L Perera, LMV Tillekeratne - Drug Discovery Today, 2021 - Elsevier
Highlights•The SARS-CoV-2 main protease is a prime drug target.•Coronavirus main
proteases share a structurally conserved substrate-binding region.•The structure and …

A smooth particle mesh Ewald method

U Essmann, L Perera, ML Berkowitz… - The Journal of …, 1995 - pubs.aip.org
The previously developed particle mesh Ewald method is reformulated in terms of efficient B‐
spline interpolation of the structure factors. This reformulation allows a natural extension of …

First observation of the Greisen-Zatsepin-Kuzmin suppression

RU Abbasi, T Abu-Zayyad, M Allen, JF Amman… - Physical review …, 2008 - APS
The High Resolution Fly's Eye (HiRes) experiment has observed the Greisen-Zatsepin-
Kuzmin suppression (called the GZK cutoff) with a statistical significance of five standard …

Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human …

KC Conlon, E Lugli, HC Welles… - Journal of clinical …, 2015 - ascopubs.org
Purpose Interleukin-15 (IL-15) has significant potential in cancer immunotherapy as an
activator of antitumor CD8 T and natural killer (NK) cells. The primary objectives of this trial …

Experimental Evidence for a Light and Broad Scalar Resonance in Decay

EM Aitala, S Amato, JC Anjos, JA Appel, D Ashery… - Physical Review Letters, 2001 - APS
From a sample of 1172±61 D+→ π− π+ π+ decays, we find Γ (D+→ π− π+ π+)/Γ (D+→ K−
π+ π+)= 0.0311±0.0018− 0.0026+ 0.0016. Using a coherent amplitude analysis to fit the …

Indications of proton-dominated cosmic-ray composition above 1.6 EeV

RU Abbasi, T Abu-Zayyad, M Al-Seady, M Allen… - Physical Review Letters, 2010 - APS
We report studies of ultrahigh-energy cosmic-ray composition via analysis of depth of air
shower maximum (X max⁡), for air shower events collected by the High-Resolution Fly's Eye …

Molecular dynamics simulation of sodium dodecyl sulfate micelle in water: micellar structural characteristics and counterion distribution

CD Bruce, ML Berkowitz, L Perera… - The Journal of Physical …, 2002 - ACS Publications
An all-atom 5 nanosecond molecular dynamics simulation of a water-solvated micelle
containing 60 sodium dodecyl sulfate monomers was performed. Structural properties such …

Many‐body effects in molecular dynamics simulations of Na+(H2O)n and Cl(H2O)n clusters

L Perera, ML Berkowitz - The Journal of chemical physics, 1991 - pubs.aip.org
Many‐body effects were examined in a series of molecular dynamics computer simulations
on the ionic aqueous clusters Na+ (H2O) n (n= 4, 5, 6, 14) and Cl−(H2O) n (n= 4, 5, 6, 7, 8 …