Proteomics profile of mesenchymal stromal cells and extracellular vesicles in normoxic and hypoxic conditions

CL Braga, LR da Silva, RT Santos, LRP de Carvalho… - Cytotherapy, 2022 - Elsevier
Background aims Although bone marrow-derived mesenchymal stromal cells (MSCs) have
demonstrated success in pre-clinical studies, they have shown only mild therapeutic effects …

Human endogenous retrovirus K in the respiratory tract is associated with COVID-19 physiopathology

JR Temerozo, N Fintelman-Rodrigues, MC Dos Santos… - Microbiome, 2022 - Springer
Background Critically ill 2019 coronavirus disease (COVID-19) patients under invasive
mechanical ventilation (IMV) are 10 to 40 times more likely to die than the general …

Platelet proteome reveals features of cell death, antiviral response and viral replication in covid-19

MRO Trugilho, IG Azevedo-Quintanilha… - Cell death …, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) has affected over 400 million people
worldwide, leading to 6 million deaths. Among the complex symptomatology of COVID-19 …

[HTML][HTML] Quantitative proteomic and phosphoproteomic analysis of Trypanosoma cruzi amastigogenesis

RML Queiroz, S Charneau, SC Mandacaru… - Molecular & Cellular …, 2014 - Elsevier
Chagas disease is a tropical neglected disease endemic in Latin America caused by the
protozoan Trypanosoma cruzi. The parasite has four major life stages: epimastigote …

Mapping salivary proteases in Sjögren's syndrome patients reveals overexpression of dipeptidyl peptidase-4/CD26

L Garreto, S Charneau, SC Mandacaru… - Frontiers in …, 2021 - frontiersin.org
Sjögren's Syndrome (SS) is an autoimmune exocrinopathy characterized by the progressive
damage of salivary and lacrimal glands associated with lymphocytic infiltration. Identifying …

Characterizing the structure and oligomerization of major royal jelly protein 1 (MRJP1) by mass spectrometry and complementary biophysical tools

SC Mandacaru, LHF do Vale, S Vahidi, Y Xiao… - Biochemistry, 2017 - ACS Publications
Royal jelly (RJ) triggers the development of female honeybee larvae into queens. This effect
has been attributed to the presence of major royal jelly protein 1 (MRJP1) in RJ. MRJP1 …

An Integrative Sialomic Analysis Reveals Molecules From Triatoma sordida (Hemiptera: Reduviidae)

YR Praça, PB Santiago, S Charneau… - Frontiers in cellular …, 2022 - frontiersin.org
Triatomines have evolved salivary glands that produce versatile molecules with various
biological functions, including those leading their interactions with vertebrate hosts' …

Proteomic profile of procoagulant extracellular vesicles reflects complement system activation and platelet hyperreactivity of patients with severe COVID-19

ECS Moraes, R Martins-Gonçalves, LR Silva… - Frontiers in Cellular …, 2022 - frontiersin.org
Background Extracellular vesicles (EVs) are a valuable source of biomarkers and display
the pathophysiological status of various diseases. In COVID-19, EVs have been explored in …

Aedes aegypti Aag-2 Cell Proteome Modulation in Response to Chikungunya Virus Infection

AF Vasconcellos, RM Melo, SC Mandacaru… - Frontiers in Cellular …, 2022 - frontiersin.org
Chikungunya virus (CHIKV) is a single-stranded positive RNA virus that belongs to the
genus Alphavirus and is transmitted to humans by infected Aedes aegypti and Aedes …

Biochemical and structural characterization of a protein complex containing a hyaluronidase and a CRISP-like protein isolated from the venom of the spider …

T Barth, SC Mandacaru, S Charneau, MV de Souza… - Journal of …, 2019 - Elsevier
Spider venoms are composed of a complex mixture of bioactive molecules. The structural
and functional characterization of these molecules in the venom of the Brazilian spider …