Ensembl (http://www. ensembl. org/) is a bioinformatics project to organize biological
information around the sequences of large genomes. It is a comprehensive source of stable …

Histone modifications are important markers of function and chromatin state, yet the DNA
sequence elements that direct them to specific genomic locations are poorly understood …

Selection acting on genomic functional elements can be detected by its indirect effects on
population diversity at linked neutral sites. To illuminate the selective forces that shaped …

While many genetic variants have been associated with risk for human diseases, how these
variants affect gene expression in various cell types remains largely unknown. To address …

Noncoding genetic variation is a major driver of phenotypic diversity, but functional
interpretation is challenging. To better understand common genetic variation associated with …

Abstract The Ensembl (http://www. ensembl. org/) project provides a comprehensive and
integrated source of annotation of large genome sequences. Over the last year the number …

Systems for managing genomic data must store a vast quantity of information. Ensembl
stores these data in several MySQL databases. The core software libraries provide a …

Allele-specific sequencing reads provide a powerful signal for identifying molecular
quantitative trait loci (QTLs), but they are challenging to analyze and are prone to technical …

Ring opening as practiced in hydrocracking of naphthenic molecules results from multiple
cleavages of both endo-and exocyclic C–C bonds. Selective ring opening requires that only …

Nucleosomes are important for gene regulation because their arrangement on the genome
can control which proteins bind to DNA. Currently, few human nucleosomes are thought to …