User profiles for "author:Krishnamachary B"
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Regulation of colon carcinoma cell invasion by hypoxia-inducible factor
B Krishnamachary, S Berg-Dixon, B Kelly… - Cancer …, 2003 - aacrjournals.org
Abstract Hypoxia-inducible factor 1 (HIF-1) transactivates genes the products of which
mediate tumor angiogenesis and glycolytic metabolism. Overexpression of the HIF-1α …
mediate tumor angiogenesis and glycolytic metabolism. Overexpression of the HIF-1α …
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
H Zhang, P Gao, R Fukuda, G Kumar… - Cancer cell, 2007 - cell.com
Many cancer cells are characterized by increased glycolysis and decreased respiration,
even under aerobic conditions. The molecular mechanisms underlying this metabolic …
even under aerobic conditions. The molecular mechanisms underlying this metabolic …
Hypoxia-Inducible Factor-1-Dependent Repression of E-cadherin in von Hippel-Lindau Tumor Suppressor–Null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A …
A critical event in the pathogenesis of invasive and metastatic cancer is E-cadherin loss of
function. Renal clear cell carcinoma (RCC) is characterized by loss of function of the von …
function. Renal clear cell carcinoma (RCC) is characterized by loss of function of the von …
RETRACTED ARTICLE: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
H Zhang, CCL Wong, H Wei, DM Gilkes, P Korangath… - Oncogene, 2012 - nature.com
Most cases of breast cancer (BrCa) mortality are due to vascular metastasis. BrCa cells must
intravasate through endothelial cells (ECs) to enter a blood vessel in the primary tumor and …
intravasate through endothelial cells (ECs) to enter a blood vessel in the primary tumor and …
Molecular imaging of the tumor microenvironment for precision medicine and theranostics
Morbidity and mortality from cancer and their associated conditions and treatments continue
to extract a heavy social and economic global burden despite the transformative advances …
to extract a heavy social and economic global burden despite the transformative advances …
Stromal cell–derived factor-1α and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces …
D Zagzag, B Krishnamachary, H Yee, H Okuyama… - Cancer …, 2005 - aacrjournals.org
The genetic hallmark of hemangioblastomas and clear cell-renal cell carcinomas (CC-
RCCs) is loss-of-function of the von Hippel-Lindau (VHL) tumor suppressor protein. VHL is …
RCCs) is loss-of-function of the von Hippel-Lindau (VHL) tumor suppressor protein. VHL is …
OS-9 interacts with hypoxia-inducible factor 1α and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1α
JH Baek, PC Mahon, J Oh, B Kelly, B Krishnamachary… - Molecular cell, 2005 - cell.com
Abstract Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen
homeostasis in metazoan species. HIF-1 mediates changes in gene transcription in …
homeostasis in metazoan species. HIF-1 mediates changes in gene transcription in …
[HTML][HTML] Hypoxia inducible-factor1α regulates the metabolic shift of pulmonary hypertensive endothelial cells
I Fijalkowska, W Xu, SAA Comhair, AJ Janocha… - The American journal of …, 2010 - Elsevier
Severe pulmonary hypertension is irreversible and often fatal. Abnormal proliferation and
resistance to apoptosis of endothelial cells (ECs) and hypertrophy of smooth muscle cells in …
resistance to apoptosis of endothelial cells (ECs) and hypertrophy of smooth muscle cells in …
Persistent circulation of soluble and extracellular vesicle‐linked Spike protein in individuals with postacute sequelae of COVID‐19
V Craddock, A Mahajan, L Spikes… - Journal of Medical …, 2023 - Wiley Online Library
ABSTRACT SARS‐CoV‐2, the causative agent of COVID‐19 disease, has resulted in the
death of millions worldwide since the beginning of the pandemic in December 2019. While …
death of millions worldwide since the beginning of the pandemic in December 2019. While …
Choline metabolism alteration: a focus on ovarian cancer
M Bagnoli, A Granata, R Nicoletti… - Frontiers in …, 2016 - frontiersin.org
Compared with normal differentiated cells, cancer cells require a metabolic reprograming to
support their high proliferation rates and survival. Aberrant choline metabolism is a fairly …
support their high proliferation rates and survival. Aberrant choline metabolism is a fairly …