(Hughes, 1994). Consistent with its role as a classical tumor suppressor gene, loss of
heterozygosity (LOH) or Introduction“second-hit” somatic mutations in the inherited wild …

DEVELOFMEIST Page 1 VOLUME 10 GENES (Eh DEVELOFMEIST NUMBER 13 PAGES
1569-1710 July 1, 1996 EDITORIAL BOARD J. Adams (Melbourne, Australia) J. Beckwith (Boston …

Metastasis accounts for the vast majority of cancer deaths. The unique challenges for
treating metastases include their small size, high multiplicity and dispersion to diverse organ …

To determine the contribution of~ 53 loss to tumor progression, we have induced abnormal
proliferation In the brain choroid plexus epithelium of transgenic mice using a SV40 T …

Background: The p53 tumor suppressor gene is mutated in a large percentage of human
malignancies, including tumors of the colon, breast, lung and brain. Individuals who inherit …

Recent work has revealed the existence of a class of small non-coding RNA species, known
as microRNAs (miRNAs), which have critical functions across various biological processes …

Summary miR-17∼ 92, miR-106b∼ 25, and miR-106a∼ 363 belong to a family of highly
conserved miRNA clusters. Amplification and overexpression of miR-17∼ 92 is observed in …

There is growing recognition that mammalian cells produce many thousands of large
intergenic transcripts,,,. However, the functional significance of these transcripts has been …

Based on precedents from other retro viruses1, the precursor of the human
immunodeficiency virus (HIV-1) reverse transcriptase is predicted to be a polyprotein with a …

To evaluate the role of oncogenic RAS mutations in pancreatic tumorigenesis, we directed
endogenous expression of KRAS G12D to progenitor cells of the mouse pancreas. We find …