The functional consequences of alternative promoter use in mammalian genomes
RV Davuluri, Y Suzuki, S Sugano, C Plass… - Trends in Genetics, 2008 - cell.com
We are beginning to appreciate the increasing complexity of mammalian gene structure. A
phenomenon that adds an important dimension to this complexity is the use of alternative …
phenomenon that adds an important dimension to this complexity is the use of alternative …
Epigenetic gene silencing in cancer initiation and progression
KP Nephew, THM Huang - Cancer letters, 2003 - Elsevier
Hypermethylation of CpG islands, an epigenetic event that is not accompanied by changes
in DNA sequence, represents an alternative mechanism to deletions or mutations to …
in DNA sequence, represents an alternative mechanism to deletions or mutations to …
Epigenetic alterations in the breast: Implications for breast cancer detection, prognosis and treatment
AM Dworkin, THM Huang, AE Toland - Seminars in cancer biology, 2009 - Elsevier
Epigenetic alterations of the genome such as DNA promoter methylation and chromatin
remodeling play an important role in tumorigenesis. Recent findings indicate epigenetic …
remodeling play an important role in tumorigenesis. Recent findings indicate epigenetic …
Identification and characterization of ovarian cancer-initiating cells from primary human tumors
The objective of this study was to identify and characterize a self-renewing subpopulation of
human ovarian tumor cells (ovarian cancer-initiating cells, OCICs) fully capable of serial …
human ovarian tumor cells (ovarian cancer-initiating cells, OCICs) fully capable of serial …
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
Epigenetic silencing in cancer cells is mediated by at least two distinct histone modifications,
polycomb-based histone H3 lysine 27 trimethylation (H3K27triM) and H3K9 dimethylation …
polycomb-based histone H3 lysine 27 trimethylation (H3K27triM) and H3K9 dimethylation …
Methylation profiling of CpG islands in human breast cancer cells
THM Huang, MR Perry, DE Laux - Human molecular genetics, 1999 - academic.oup.com
CpG island hypermethylation is known to be associated with gene silencing in cancer. This
epigenetic event is generally accepted as a stochastic process in tumor cells resulting from …
epigenetic event is generally accepted as a stochastic process in tumor cells resulting from …
[HTML][HTML] FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene
T Zuo, L Wang, C Morrison, X Chang, H Zhang, W Li… - Cell, 2007 - cell.com
The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family.
Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we …
Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we …
Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis
AS Weinmann, PS Yan, MJ Oberley… - Genes & …, 2002 - genesdev.cshlp.org
Previously, identification of promoters regulated by mammalian transcription factors has
relied upon overexpression studies. Here we present the identification of a large set of …
relied upon overexpression studies. Here we present the identification of a large set of …
[HTML][HTML] Methyl‐CpG binding proteins identify novel sites of epigenetic inactivation in human cancer
E Ballestar, MF Paz, L Valle, S Wei, MF Fraga… - The EMBO …, 2003 - embopress.org
Methyl‐CpG binding proteins (MBDs) mediate histone deacetylase‐dependent
transcriptional silencing at methylated CpG islands. Using chromatin immunoprecitation …
transcriptional silencing at methylated CpG islands. Using chromatin immunoprecitation …
Epigenetic Repression of microRNA-129-2 Leads to Overexpression of SOX4 Oncogene in Endometrial Cancer
YW Huang, JC Liu, DE Deatherage, J Luo, DG Mutch… - Cancer research, 2009 - AACR
Genetic amplification, mutation, and translocation are known to play a causal role in the
upregulation of an oncogene in cancer cells. Here, we report an emerging role of microRNA …
upregulation of an oncogene in cancer cells. Here, we report an emerging role of microRNA …