Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease
Summary Sporadic Creutzfeldt-Jakob disease is a fatal neurodegenerative disease caused
by misfolded prion proteins (PrP Sc). Effective therapeutics are currently not available and …
by misfolded prion proteins (PrP Sc). Effective therapeutics are currently not available and …
Neuroinvasion of SARS-CoV-2 in human and mouse brain
Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects
multiple organ systems including the central nervous system (CNS). Yet, there is no …
multiple organ systems including the central nervous system (CNS). Yet, there is no …
Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease
Several molecular subtypes of sporadic Creutzfeldt–Jakob disease have been identified and
electroencephalogram and cerebrospinal fluid biomarkers have been reported to support …
electroencephalogram and cerebrospinal fluid biomarkers have been reported to support …
Potential human transmission of amyloid β pathology: surveillance and risks
E Lauwers, G Lalli, S Brandner, J Collinge… - The Lancet …, 2020 - thelancet.com
Studies in experimental animals show transmissibility of amyloidogenic proteins associated
with prion diseases, Alzheimer's disease, Parkinson's disease, and other neurodegenerative …
with prion diseases, Alzheimer's disease, Parkinson's disease, and other neurodegenerative …
[HTML][HTML] The 37‐kDa/67‐kDa laminin receptor acts as the cell‐surface receptor for the cellular prion protein
S Gauczynski, JM Peyrin, S Haïk, C Leucht… - The EMBO …, 2001 - embopress.org
The 37‐kDa/67‐kDa laminin receptor acts as the cell‐surface receptor for the cellular prion
protein | The EMBO Journal logo embp press logo JOURNALS The EMBO Journal The EMBO …
protein | The EMBO Journal logo embp press logo JOURNALS The EMBO Journal The EMBO …
Quantifying prion disease penetrance using large population control cohorts
EV Minikel, SM Vallabh, M Lek, K Estrada… - Science translational …, 2016 - science.org
More than 100,000 genetic variants are reported to cause Mendelian disease in humans,
but the penetrance—the probability that a carrier of the purported disease-causing genotype …
but the penetrance—the probability that a carrier of the purported disease-causing genotype …
Conserved meningeal lymphatic drainage circuits in mice and humans
L Jacob, J de Brito Neto, S Lenck, C Corcy… - Journal of Experimental …, 2022 - rupress.org
Meningeal lymphatic vessels (MLVs) were identified in the dorsal and caudobasal regions of
the dura mater, where they ensure waste product elimination and immune surveillance of …
the dura mater, where they ensure waste product elimination and immune surveillance of …
[HTML][HTML] Identification of interaction domains of the prion protein with its 37‐kDa/67‐kDa laminin receptor
C Hundt, JM Peyrin, S Haïk, S Gauczynski… - The EMBO …, 2001 - embopress.org
Identification of interaction domains of the prion protein with its 37‐kDa/67‐kDa laminin
receptor | The EMBO Journal logo embp press logo JOURNALS The EMBO Journal The EMBO …
receptor | The EMBO Journal logo embp press logo JOURNALS The EMBO Journal The EMBO …
Prions in the urine of patients with variant Creutzfeldt–Jakob disease
F Moda, P Gambetti, S Notari… - … England Journal of …, 2014 - Mass Medical Soc
Background Prions, the infectious agents responsible for transmissible spongiform
encephalopathies, consist mainly of the misfolded prion protein (PrPSc). The unique …
encephalopathies, consist mainly of the misfolded prion protein (PrPSc). The unique …
Doxycycline in Creutzfeldt-Jakob disease: a phase 2, randomised, double-blind, placebo-controlled trial
S Haïk, G Marcon, A Mallet, M Tettamanti… - The Lancet …, 2014 - thelancet.com
Summary Background Creutzfeldt-Jakob disease (CJD) is a fatal, untreatable prion
encephalopathy. Previous studies showed that doxycycline is effective in in-vitro and in-vivo …
encephalopathy. Previous studies showed that doxycycline is effective in in-vitro and in-vivo …