User profiles for "author:Hägglöf T"
 | Thomas HägglöfAlbert Einstein College of Medicine Verified email at einsteinmed.edu Cited by 5497 |
IL-18 in inflammatory and autoimmune disease
SK Sedimbi, T Hägglöf, MCI Karlsson - Cellular and molecular life …, 2013 - Springer
Inflammation serves as the first line of defense in response to tissue injury, guiding the
immune system to ensure preservation of the host. The inflammatory response can be …
immune system to ensure preservation of the host. The inflammatory response can be …
Convergent antibody responses to SARS-CoV-2 in convalescent individuals
During the coronavirus disease-2019 (COVID-19) pandemic, severe acute respiratory
syndrome-related coronavirus-2 (SARS-CoV-2) has led to the infection of millions of people …
syndrome-related coronavirus-2 (SARS-CoV-2) has led to the infection of millions of people …
Evolution of antibody immunity to SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected 78 million
individuals and is responsible for over 1.7 million deaths to date. Infection is associated with …
individuals and is responsible for over 1.7 million deaths to date. Infection is associated with …
[HTML][HTML] Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies
CO Barnes, AP West, KE Huey-Tubman… - Cell, 2020 - cell.com
Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain
(RBD) of the trimeric spike. Here, we characterized polyclonal immunoglobulin Gs (IgGs) …
(RBD) of the trimeric spike. Here, we characterized polyclonal immunoglobulin Gs (IgGs) …
Persistent cellular immunity to SARS-CoV-2 infection
SARS-CoV-2 is responsible for an ongoing pandemic that has affected millions of
individuals around the globe. To gain further understanding of the immune response in …
individuals around the globe. To gain further understanding of the immune response in …
Continuous germinal center invasion contributes to the diversity of the immune response
Antibody responses are characterized by increasing affinity and diversity over time. Affinity
maturation occurs in germinal centers by a mechanism that involves repeated cycles of …
maturation occurs in germinal centers by a mechanism that involves repeated cycles of …
T-bet+ B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity
Obesity is accompanied by inflammation in adipose tissue, impaired glucose tolerance, and
changes in adipose leukocyte populations. These studies of adipose tissue from humans …
changes in adipose leukocyte populations. These studies of adipose tissue from humans …
Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response
EK Grasset, A Duhlin, HE Agardh… - Proceedings of the …, 2015 - pnas.org
The B-cell response in atherosclerosis is directed toward oxidation-specific epitopes such as
phosphorylcholine (PC) that arise during disease-driven oxidation of self-antigens. PC …
phosphorylcholine (PC) that arise during disease-driven oxidation of self-antigens. PC …
The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells
SL Enoksson, EK Grasset, T Hägglöf… - Proceedings of the …, 2011 - pnas.org
Inflammatory responses initiate rapid production of IL-1 family cytokines, including IL-18.
This cytokine is produced at high levels in inflammatory diseases, including allergy and …
This cytokine is produced at high levels in inflammatory diseases, including allergy and …
Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses
The innate responsiveness of the immune system is important not only for quick responses
to pathogens but also for the initiation and shaping of the subsequent adaptive immune …
to pathogens but also for the initiation and shaping of the subsequent adaptive immune …