MicroRNAs (miRNAs) are short non‐coding RNAs that modulate physiological and
pathological processes by inhibiting target gene expression via blockade of protein …

HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis.
Recent studies have defined posttranslational modification by prolyl hydroxylation as a key …

The optimal delivery of oxygen to tissues is essential both to ensure adequate energy
provision and to avoid the toxic effects of higher oxygen concentrations. For this to occur …

Recent studies of tissue culture cells have defined a widespread system of oxygen-
regulated gene expression based on the activation of a heterodimeric transcription factor …

Hypoxia-inducible factor (HIF) is a transcriptional regulator that plays a key role in many
aspects of oxygen homeostasis. The heterodimeric HIF complex is regulated by proteolysis …

Activity of the hypoxia-inducible factor (HIF) complex is controlled by oxygen-dependent
hydroxylation of prolyl and asparaginyl residues. Hydroxylation of specific prolyl residues by …

Background Exosomes are nanovesicles secreted by tumour cells which have roles in
paracrine signalling during tumour progression, including tumour-stromal interactions …

Exosomes are membrane‐bound vesicles of endosomal origin, present in a wide range of
biological fluids, including blood and urine. They range between 30 and 100 nm in diameter …

Hypoxia-inducible factor-1 (HIF-1), a heterodimeric DNA binding complex composed of two
basic-helix-loop-helix Per-AHR-ARNT-Sim proteins (HIF-1α and− 1β), is a key component of …

Purpose: MicroRNA (miRNA) expression alterations have been described in cancer. Many
cancers are characterized by areas of hypoxia, enhanced hypoxia-inducible factor (HIF) …