SHARPIN is a ubiquitin-binding and ubiquitin-like-domain-containing protein which, when
mutated in mice, results in immune system disorders and multi-organ inflammation,. Here we …

Protein kinase D (PKD) is a cytosolic serine/threonine kinase implicated in regulation of
several cellular processes such as response to oxidative stress, directed cell migration …

Unc-51-like kinase 1 (Ulk1) plays a central role in autophagy induction. It forms a stable
complex with Atg13 and focal adhesion kinase (FAK) family interacting protein of 200 kDa …

In every living organism, cell division requires accurate identification of the division site and
placement of the division machinery. In bacteria, this process is traditionally considered to …

Autophagy is controlled by AMPK and mTOR, both of which associate with ULK1 and control
the production of phosphatidylinositol 3-phosphate (PtdIns3P), a prerequisite for …

Many microorganisms excrete typical cytoplasmic proteins into the culture supernatant. As
none of the classical secretion systems appears to be involved, this type of secretion was …

Background The Nod-like receptor NACHT, LRR, and PYD domain–containing protein 3
(NLRP3) and Bruton tyrosine kinase (BTK) are protagonists in innate and adaptive immunity …

Abstract Background The marine annelid Platynereis dumerilii is emerging as a powerful
lophotrochozoan experimental model for evolutionary developmental biology (evo-devo) …

The host endolysosomal compartment is often manipulated by intracellular bacterial
pathogens. Salmonella (Salmonella enterica serovar Typhimurium) secrete numerous …

Sepsis caused by Gram-positive bacterial pathogens is a major fatal disease but its
molecular basis remains elusive. Toll-like receptor 2 (TLR2) has been implicated in the …