Autism as a disorder of neural information processing: directions for research and targets for therapy
MK Belmonte, EH Cook, GM Anderson… - Molecular …, 2004 - nature.com
The broad variation in phenotypes and severities within autism spectrum disorders suggests
the involvement of multiple predisposing factors, interacting in complex ways with normal …
the involvement of multiple predisposing factors, interacting in complex ways with normal …
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …
A single-cell survey of the small intestinal epithelium
Intestinal epithelial cells absorb nutrients, respond to microbes, function as a barrier and
help to coordinate immune responses. Here we report profiling of 53,193 individual …
help to coordinate immune responses. Here we report profiling of 53,193 individual …
Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor delta subunit knockout mice
RM Mihalek, PK Banerjee, ER Korpi, JJ Quinlan… - Proceedings of the …, 1999 - pnas.org
γ-Aminobutyric acid (GABA) type A receptors mediate fast inhibitory synaptic transmission
and have been implicated in responses to sedative/hypnotic agents (including neuroactive …
and have been implicated in responses to sedative/hypnotic agents (including neuroactive …
Mice lacking the β3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome
TM DeLorey, A Handforth, SG Anagnostaras… - Journal of …, 1998 - jneurosci.org
Angelman syndrome (AS) is a severe neurodevelopmental disorder resulting from a
deletion/mutation in maternal chromosome 15q11–13. The genes in 15q11–13 contributing …
deletion/mutation in maternal chromosome 15q11–13. The genes in 15q11–13 contributing …
Mice devoid of γ-aminobutyrate type A receptor β3 subunit have epilepsy, cleft palate, and hypersensitive behavior
GE Homanics, TM DeLorey, LL Firestone… - Proceedings of the …, 1997 - pnas.org
γ-Aminobutyric acid type A receptors (GABAA-Rs) mediate the bulk of rapid inhibitory
synaptic transmission in the central nervous system. The β3 subunit is an essential …
synaptic transmission in the central nervous system. The β3 subunit is an essential …
A scalable, fully automated process for construction of sequence-ready human exome targeted capture libraries
S Fisher, A Barry, J Abreu, B Minie, J Nolan… - Genome biology, 2011 - Springer
Genome targeting methods enable cost-effective capture of specific subsets of the genome
for sequencing. We present here an automated, highly scalable method for carrying out the …
for sequencing. We present here an automated, highly scalable method for carrying out the …
B-cell-specific checkpoint molecules that regulate anti-tumour immunity
The role of B cells in anti-tumour immunity is still debated and, accordingly,
immunotherapies have focused on targeting T and natural killer cells to inhibit tumour …
immunotherapies have focused on targeting T and natural killer cells to inhibit tumour …
Reciprocal inhibitory connections and network synchrony in the mammalian thalamus
Neuronal rhythmic activities within thalamocortical circuits range from partially synchronous
oscillations during normal sleep to hypersynchrony associated with absence epilepsy. It has …
oscillations during normal sleep to hypersynchrony associated with absence epilepsy. It has …
[HTML][HTML] Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity
While intestinal Th17 cells are critical for maintaining tissue homeostasis, recent studies
have implicated their roles in the development of extra-intestinal autoimmune diseases …
have implicated their roles in the development of extra-intestinal autoimmune diseases …