Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease

C O'Neill, AP Kiely, MF Coakley… - Biochemical Society …, 2012 - portlandpress.com
The quality control of protein homoeostasis deteriorates with aging, causing the
accumulation of misfolded proteins and neurodegeneration. Thus, in AD (Alzheimer's …

Gut microbiota composition correlates with diet and health in the elderly

MJ Claesson, IB Jeffery, S Conde, SE Power… - Nature, 2012 - nature.com
Alterations in intestinal microbiota composition are associated with several chronic
conditions, including obesity and inflammatory diseases. The microbiota of older people …

Challenges facing development of probiotic-containing functional foods

C Stanton, C Desmond, M Coakley… - Handbook of …, 2003 - books.google.com
There is ever-increasing evidence to support potential clinical applications of probiotics in
the prevention and treatment of diseases of the gastrointestinal, respiratory, and urogenital …

Conjugated linoleic acid biosynthesis by human‐derived Bifidobacterium species

M Coakley, RP Ross, M Nordgren… - Journal of applied …, 2003 - academic.oup.com
Aims: To assess strains of Lactobacillus, Lactococcus, Pediococcus and Bifidobacterium for
their ability to produce the health‐promoting fatty acid conjugated linoleic acid (CLA) from …

Bioinformatic approaches for studying the microbiome of fermented food

LH Walsh, M Coakley, AM Walsh… - Critical Reviews in …, 2023 - Taylor & Francis
High-throughput DNA sequencing-based approaches continue to revolutionise our
understanding of microbial ecosystems, including those associated with fermented foods …

Transfusion triggers in orthotopic liver transplantation: a comparison of the thromboelastometry analyzer, the thromboelastogram, and conventional coagulation tests

M Coakley, K Reddy, I Mackie, S Mallett - Journal of cardiothoracic and …, 2006 - Elsevier
Objectives: The Thromboelastogram (TEG; Haemoscope Corporation, Niles, IL) and the
ROTEM thromboelastometry analyzer (Pentapharm GmbH, Munich, Germany) are …

[HTML][HTML] Metabolic activity of the enteric microbiota influences the fatty acid composition of murine and porcine liver and adipose tissues

R Wall, RP Ross, F Shanahan, L O'Mahony… - The American journal of …, 2009 - Elsevier
Background Recent reports suggest that the metabolic activity of the gut microbiota may
contribute to the pathogenesis of obesity and hepatic steatosis. Objective: The objective was …

Akt signal transduction dysfunction in Parkinson's disease

S Timmons, MF Coakley, AM Moloney, C O'Neill - Neuroscience letters, 2009 - Elsevier
Significant attention has been drawn to the potential role of defective PI3-kinase-Akt (PKB)
signalling in Parkinson's disease (PD) neurodegeneration and to the possibility that …

[HTML][HTML] Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiome

N Carlino, A Blanco-Míguez, M Punčochář, C Mengoni… - Cell, 2024 - cell.com
Complex microbiomes are part of the food we eat and influence our own microbiome, but
their diversity remains largely unexplored. Here, we generated the open access …

The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in …

CM Long-Smith, S Manning, PL McClean… - Neuromolecular …, 2013 - Springer
Alzheimer's disease (AD) has been shown to involve desensitised insulin receptor (IR)
signalling. Liraglutide, a novel glucagon-like peptide 1 (GLP-1) analogue that facilitates …