Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease
C O'Neill, AP Kiely, MF Coakley… - Biochemical Society …, 2012 - portlandpress.com
The quality control of protein homoeostasis deteriorates with aging, causing the
accumulation of misfolded proteins and neurodegeneration. Thus, in AD (Alzheimer's …
accumulation of misfolded proteins and neurodegeneration. Thus, in AD (Alzheimer's …
Gut microbiota composition correlates with diet and health in the elderly
MJ Claesson, IB Jeffery, S Conde, SE Power… - Nature, 2012 - nature.com
Alterations in intestinal microbiota composition are associated with several chronic
conditions, including obesity and inflammatory diseases. The microbiota of older people …
conditions, including obesity and inflammatory diseases. The microbiota of older people …
Challenges facing development of probiotic-containing functional foods
C Stanton, C Desmond, M Coakley… - Handbook of …, 2003 - books.google.com
There is ever-increasing evidence to support potential clinical applications of probiotics in
the prevention and treatment of diseases of the gastrointestinal, respiratory, and urogenital …
the prevention and treatment of diseases of the gastrointestinal, respiratory, and urogenital …
Conjugated linoleic acid biosynthesis by human‐derived Bifidobacterium species
M Coakley, RP Ross, M Nordgren… - Journal of applied …, 2003 - academic.oup.com
Aims: To assess strains of Lactobacillus, Lactococcus, Pediococcus and Bifidobacterium for
their ability to produce the health‐promoting fatty acid conjugated linoleic acid (CLA) from …
their ability to produce the health‐promoting fatty acid conjugated linoleic acid (CLA) from …
Bioinformatic approaches for studying the microbiome of fermented food
LH Walsh, M Coakley, AM Walsh… - Critical Reviews in …, 2023 - Taylor & Francis
High-throughput DNA sequencing-based approaches continue to revolutionise our
understanding of microbial ecosystems, including those associated with fermented foods …
understanding of microbial ecosystems, including those associated with fermented foods …
Transfusion triggers in orthotopic liver transplantation: a comparison of the thromboelastometry analyzer, the thromboelastogram, and conventional coagulation tests
M Coakley, K Reddy, I Mackie, S Mallett - Journal of cardiothoracic and …, 2006 - Elsevier
Objectives: The Thromboelastogram (TEG; Haemoscope Corporation, Niles, IL) and the
ROTEM thromboelastometry analyzer (Pentapharm GmbH, Munich, Germany) are …
ROTEM thromboelastometry analyzer (Pentapharm GmbH, Munich, Germany) are …
[HTML][HTML] Metabolic activity of the enteric microbiota influences the fatty acid composition of murine and porcine liver and adipose tissues
Background Recent reports suggest that the metabolic activity of the gut microbiota may
contribute to the pathogenesis of obesity and hepatic steatosis. Objective: The objective was …
contribute to the pathogenesis of obesity and hepatic steatosis. Objective: The objective was …
Akt signal transduction dysfunction in Parkinson's disease
S Timmons, MF Coakley, AM Moloney, C O'Neill - Neuroscience letters, 2009 - Elsevier
Significant attention has been drawn to the potential role of defective PI3-kinase-Akt (PKB)
signalling in Parkinson's disease (PD) neurodegeneration and to the possibility that …
signalling in Parkinson's disease (PD) neurodegeneration and to the possibility that …
[HTML][HTML] Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiome
Complex microbiomes are part of the food we eat and influence our own microbiome, but
their diversity remains largely unexplored. Here, we generated the open access …
their diversity remains largely unexplored. Here, we generated the open access …
The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in …
CM Long-Smith, S Manning, PL McClean… - Neuromolecular …, 2013 - Springer
Alzheimer's disease (AD) has been shown to involve desensitised insulin receptor (IR)
signalling. Liraglutide, a novel glucagon-like peptide 1 (GLP-1) analogue that facilitates …
signalling. Liraglutide, a novel glucagon-like peptide 1 (GLP-1) analogue that facilitates …