Two-component systems, composed of a homodimeric histidine kinase (HK) and a response
regulator (RR), are major signal transduction devices in bacteria. Typically the signal …

BACKGROUND Patients with essential hypertension have abnormal endothelium-
dependent vasodilation. Because the endothelium exerts its action on the vascular smooth …

BACKGROUND Patients with hypercholesterolemia have a reduced response to
endothelium-dependent vasodilators. However, the regulatory function of the endothelium …

The chief mechanism used by bacteria for sensing their environment is based on two
conserved proteins: a sensor histidine kinase (HK) and an effector response regulator (RR) …

BACKGROUND Endothelium-derived nitric oxide is an important modulator of resting
vascular tone in animals and humans. However, the contribution of nitric oxide to exercise …

BACKGROUND Patients with essential hypertension have a deficit in the endothelium-
derived nitric oxide system that results in impaired endothelium-dependent vascular …

Reversible protein phosphorylation is the most widespread regulatory mechanism in signal
transduction. Autophosphorylation in a dimeric sensor histidine kinase is the first step in two …

Objectives. The purpose of this study was to determine whether the impaired endothelium-
dependent vasodilation of hypertensive patients is related to a specific defect of the …

Bacillus thuringiensis Vip3 (V egetative I nsecticidal P rotein 3) toxins are widely used in
biotech crops to control Lepidopteran pests. These proteins are produced as inactive …

Abstract CIBER (Center for Biomedical Network Research; Centro de Investigación
Biomédica En Red) is a public national consortium created in 2006 under the umbrella of …