User profiles for "author:Bou-Habib DC"

Dumith Chequer Bou-Habib

Pesquisador, Instituto Oswaldo Cruz/Fiocruz
Verified email at ioc.fiocruz.br
Cited by 3678

SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes

AC Ferreira, VC Soares… - Cell death …, 2021 - nature.com
Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been
associated with leukopenia and uncontrolled inflammatory response in critically ill patients …

Cryptic nature of envelope V3 region epitopes protects primary monocytotropic human immunodeficiency virus type 1 from antibody neutralization

DC Bou-Habib, G Roderiquez, T Oravecz… - Journal of …, 1994 - journals.asm.org
Characterization of biological and immunological properties of human immunodeficiency
virus type 1 (HIV-1) is critical to developing effective therapies and vaccines for AIDS. With …

Cell-surface heparan sulfate proteoglycan mediates HIV-1 infection of T-cell lines

M Patel, M Yanagishita, G Roderiquez… - AIDS research and …, 1993 - liebertpub.com
The role of cell-surface proteoglycans in human immunodeficiency virus (HIV) infection of T-
cell lines was investigated. HIV-1-susceptible lymphoblastic T-cell lines, MT-4 and H9, were …

Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators

SSG Dias, VC Soares, AC Ferreira… - PLoS …, 2020 - journals.plos.org
Viruses are obligate intracellular parasites that make use of the host metabolic machineries
to meet their biosynthetic needs. Thus, identifying the host pathways essential for the virus …

Antileishmanial Activity of an Indole Alkaloid fromPeschiera australis

JC Delorenzi, M Attias, CR Gattass… - Antimicrobial Agents …, 2001 - journals.asm.org
In this study, we show the leishmanicidal effects of a chloroform fraction (CLF) and a purified
indole alkaloid obtained from crude stem extract of Peschiera australis against Leishmania …

Mediation of human immunodeficiency virus type 1 binding by interaction of cell surface heparan sulfate proteoglycans with the V3 region of envelope gp120-gp41

G Roderiquez, T Oravecz, M Yanagishita… - Journal of …, 1995 - journals.asm.org
The mechanism of heparan sulfate (HS)-mediated human immunodeficiency virus type 1
(HIV-1) binding to and infection of T cells was investigated with a clone (H9h) of the T-cell …

In vitro antiviral activity of the anti-HCV drugs daclatasvir and sofosbuvir against SARS-CoV-2, the aetiological agent of COVID-19

CQ Sacramento, N Fintelman-Rodrigues… - Journal of …, 2021 - academic.oup.com
Background Current approaches of drug repurposing against COVID-19 have not proven
overwhelmingly successful and the SARS-CoV-2 pandemic continues to cause major global …

IL-1β blockade attenuates thrombosis in a neutrophil extracellular trap-dependent breast cancer model

T Gomes, CBS Várady, AL Lourenço… - Frontiers in …, 2019 - frontiersin.org
Cancer patients are at increased risk of developing thrombosis, comorbidity that has been
associated with increased neutrophil counts and the formation of neutrophil extracellular …

Neuroendocrine control of macrophage development and function

AD Jurberg, V Cotta-de-Almeida, JR Temerozo… - Frontiers in …, 2018 - frontiersin.org
Macrophages carry out numerous physiological activities that are essential for both systemic
and local homeostasis, as well as innate and adaptive immune responses. Their biology is …

Simvastatin downregulates the SARS-CoV-2-induced inflammatory response and impairs viral infection through disruption of lipid rafts

L Teixeira, JR Temerozo, FS Pereira-Dutra… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is currently a worldwide emergency caused by
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In observational clinical …