Although COVID-19 is most well known for causing substantial respiratory pathology, it can
also result in several extrapulmonary manifestations. These conditions include thrombotic …

Although familial clustering of venous thromboembolic events was observed at the start of
this century, it was not until the late nineteenseventies before our insight into the …

In October 2022, these guidelines were reviewed by an expert work group convened by
ASH. Review included limited searches for new evidence and discussion of the search …

Background Prophylaxis for venous thromboembolism is recommended for at least 10 days
after total knee arthroplasty; oral regimens could enable shorter hospital stays. We aimed to …

Numerous investigators have postulated that a hypercoagulable state exists in humans for a
period of time before the development of thrombotic episodes. A clear biochemical definition …

Background Standard therapy to prevent recurrent venous thromboembolism includes 3 to
12 months of treatment with full-dose warfarin with a target international normalized ratio …

Background Orthopedic surgery remains a condition at high risk of venous
thromboembolism (VTE). Fondaparinux, the first of a new class of synthetic selective factor …

This chapter describes the pharmacology of approved parenteral anticoagulants, including
the indirect anticoagulants, unfractionated heparin (UFH), low-molecular-weight heparins …

BACKGROUND The blood coagulation system is activated in the acute phase of unstable
angina and acute myocardial infarction. However, it remains unclear whether augmented …

Tumor necrosis factor has been implicated in the activation of blood coagulation in
septicemia, a condition commonly associated with intravascular coagulation and …