Abstract Background Upon SARS-CoV-2 infection, most individuals develop neutralizing
antibodies and T-cell immunity. However, some individuals reportedly remain SARS-CoV-2 …

Viral pathogens continue to constitute a heavy burden on healthcare and socioeconomic
systems. Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and …

In this article a library of polymeric therapeutic agents against the human immunodeficiency
virus (HIV) is presented. The library of statistical copolymers of varied molar mass was …

Albumin is a highly successful tool of drug delivery providing drastically extended body and
blood residence time for the associated cargo, but it only traffics single drug copies at a time …

Antiretroviral therapy (ART) has revolutionized HIV treatment, yet grand challenges
remain:(i) short blood and body residence time of the antiviral drugs,(ii) relative poor …

Macromolecular (pro) drugs hold much promise as broad-spectrum antiviral agents as either
microbicides or carriers for intracellular delivery of antiviral drugs. Intriguing opportunity …

Humanized mouse models are used extensively in research involving human pathogens
and diseases. However, most of these models require preconditioning. Radio-active sources …

Immunotherapy is a promising therapeutic area in cancer and chronic viral infections. An
important component of immunotherapy in these contexts is the activation of innate …

It is well understood that the STING signalling pathway is critical for generating a robust
innate immune response to pathogens. Human and mouse STING signalling pathways are …

Humanized mice provide a sophisticated platform to study human immunodeficiency virus
(HIV) virology and to test antiviral drugs. This protocol describes the establishment of a …