User profiles for "author:Aepfelbacher M"

Aepfelbacher, M.

Professor of Medical Microbiology
Verified email at uke.de
Cited by 24483

Podosomes: adhesion hot-spots of invasive cells

S Linder, M Aepfelbacher - Trends in cell biology, 2003 - cell.com
Podosomes are highly dynamic, actin-rich adhesion structures of monocyte-derived cells,
certain transformed fibroblasts and carcinoma cells and have recently also been discovered …

Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study

D Wichmann, JP Sperhake… - Annals of internal …, 2020 - acpjournals.org
Background: The new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), has caused more than 210 000 deaths worldwide. However, little is known about …

Multiorgan and renal tropism of SARS-CoV-2

VG Puelles, M Lütgehetmann… - … England Journal of …, 2020 - Mass Medical Soc
Multiorgan and Renal Tropism of SARS-CoV-2 In this autopsy series, the authors found that
SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys …

Neuropathology of patients with COVID-19 in Germany: a post-mortem case series

J Matschke, M Lütgehetmann, C Hagel… - The Lancet …, 2020 - thelancet.com
Background Prominent clinical symptoms of COVID-19 include CNS manifestations.
However, it is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human …

W Siess, KJ Zangl, M Essler, M Bauer, R Brandl… - Proceedings of the …, 1999 - pnas.org
Oxidized low density lipoprotein (LDL) is a key factor in the pathogenesis of atherosclerosis
and its thrombotic complications, such as stroke and myocardial infarction. It activates …

Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?

D Jonigk, C Werlein, T Acker, M Aepfelbacher… - Virchows Archiv, 2022 - Springer
The use of autopsies in medicine has been declining. The COVID-19 pandemic has
documented and rejuvenated the importance of autopsies as a tool of modern medicine. In …

Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells

M Essler, M Amano, HJ Kruse, K Kaibuchi… - Journal of Biological …, 1998 - jbc.org
The role of Rho GTPase and its downstream targets Rho kinase and myosin light chain
phosphatase in thrombin-induced endothelial cell contraction was investigated. The specific …

Open-Source Genomic Analysis of Shiga-Toxin–Producing E. coli O104:H4

H Rohde, J Qin, Y Cui, D Li, NJ Loman… - … England Journal of …, 2011 - Mass Medical Soc
An outbreak caused by Shiga-toxin–producing Escherichia coli O104: H4 occurred in
Germany in May and June of 2011, with more than 3000 persons infected. Here, we report a …

Dying with SARS-CoV-2 infection—an autopsy study of the first consecutive 80 cases in Hamburg, Germany

C Edler, AS Schröder, M Aepfelbacher, A Fitzek… - International journal of …, 2020 - Springer
Autopsies of deceased with a confirmed severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection can provide important insights into the novel disease and its course …

Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages

S Linder, D Nelson, M Weiss… - Proceedings of the …, 1999 - pnas.org
Wiskott-Aldrich syndrome protein (WASp) is a hematopoietic-specific, multidomain protein
whose mutation is responsible for the immunodeficiency disorder Wiskott-Aldrich syndrome …