Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
Maintaining research and development (R&D) productivity at a sustainable level is one of
the main challenges currently facing the pharmaceutical industry. In this article, we discuss …
the main challenges currently facing the pharmaceutical industry. In this article, we discuss …
Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease
L George, CE Brightling - Therapeutic advances in chronic …, 2016 - journals.sagepub.com
The chronic lung diseases, asthma and chronic obstructive pulmonary disease (COPD), are
common affecting over 500 million people worldwide and causing substantial morbidity and …
common affecting over 500 million people worldwide and causing substantial morbidity and …
Targeting the interleukin pathway in the treatment of asthma
KF Chung - The Lancet, 2015 - thelancet.com
Asthma is a common heterogeneous disease with a complex pathophysiology. Current
therapies based on inhaled corticosteroids and longacting β 2 agonists are effective in …
therapies based on inhaled corticosteroids and longacting β 2 agonists are effective in …
Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group …
Background Eosinophilic airway inflammation is often present in asthma, and reduction of
such inflammation results in improved clinical outcomes. We hypothesised that fevipiprant …
such inflammation results in improved clinical outcomes. We hypothesised that fevipiprant …
Allergen-induced increases in sputum levels of group 2 innate lymphoid cells in subjects with asthma
Rationale: Group 2 innate lymphoid cells (ILC2), a major source of type 2 cytokines, initiate
eosinophilic inflammatory responses in murine models of asthma. Objectives: To investigate …
eosinophilic inflammatory responses in murine models of asthma. Objectives: To investigate …
The prostaglandin D2 receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung
Group 2 innate lymphoid cells (ILC2s) promote type 2 cytokine-dependent immunity,
inflammation, and tissue repair. Although epithelial cell-derived cytokines regulate ILC2 …
inflammation, and tissue repair. Although epithelial cell-derived cytokines regulate ILC2 …
Asthma phenotyping: a necessity for improved therapeutic precision and new targeted therapies
KF Chung - Journal of internal medicine, 2016 - Wiley Online Library
Asthma is a common heterogeneous disease with a complex pathophysiology that carries a
significant mortality rate and high morbidity. Current therapies based on inhaled …
significant mortality rate and high morbidity. Current therapies based on inhaled …
Prostaglandin D2: a dominant mediator of aspirin-exacerbated respiratory disease
Background Aspirin desensitization followed by high-dose aspirin therapy is routinely
performed for patients with aspirin-exacerbated respiratory disease (AERD). Little is known …
performed for patients with aspirin-exacerbated respiratory disease (AERD). Little is known …
Prostaglandin D2 pathway upregulation: relation to asthma severity, control, and TH2 inflammation
ML Fajt, SL Gelhaus, B Freeman, CE Uvalle… - Journal of allergy and …, 2013 - Elsevier
BACKGROUND: Bronchoalveolar lavage (BAL) fluid prostaglandin D2 (PGD2) levels are
increased in patients with severe, poorly controlled asthma in association with epithelial …
increased in patients with severe, poorly controlled asthma in association with epithelial …
G protein–coupled receptors in asthma therapy: pharmacology and drug action
Asthma is a heterogeneous inflammatory disease of the airways that is associated with
airway hyperresponsiveness and airflow limitation. Although asthma was once simply …
airway hyperresponsiveness and airflow limitation. Although asthma was once simply …