Cancer cells undergo metabolic reprogramming such as enhanced aerobic glycolysis,
mutations in the tricarboxylic acid cycle enzymes, and upregulation of de novo lipid …

Simple Summary Dysregulated glutamine metabolism is one of the metabolic features
evident in cancer cells when compared to normal cells. Cancer cells utilize glutamine for …

Autophagy is a self-eating process of using lysosomes to degrade macromolecular
substances (eg, proteins and organelles) that are damaged, degenerated, or aging. Lipid …

Simple Summary The breakthrough of immunotherapy in melanoma has generated a
glimmer of hope for lethal triple negative breast cancer (TNBC). This review summarizes the …

Plasma and tumor caveolin-1 (Cav-1) are linked with disease progression in prostate
cancer. Here we report that metabolomic profiling of longitudinal plasmas from a prospective …

Autophagy, a lysosomal catabolic process, involves degradation of cellular materials,
protein aggregate, and dysfunctional organelles to maintain cellular homeostasis. Strikingly …

Targeted therapies against cancer have improved both survival and quality of life of patients.
However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic …

Adiposity is associated with an increased risk of various types of carcinoma. One of the
plausible mechanisms underlying the tumor-promoting role of obesity is an aberrant …

The macronutrients glucose, lipids, and amino acids are the major components that maintain
life. The ability of cells to sense and respond to fluctuations in these nutrients is a crucial …

Triple-negative breast cancers (TNBCs) lack progesterone and estrogen receptors and do
not have amplified human epidermal growth factor receptor 2, the main therapeutic targets …