Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

The prevalence of diabetes is rapidly increasing and closely associated with cardiovascular
morbidity and mortality. While the major cardiovascular complication associated with …

Calcium/calmodulin-dependent protein kinase II (CaMKII) is upregulated in diabetes and
significantly contributes to cardiac remodeling with increased risk of cardiac arrhythmias …

Abstract Connexin 43 (Cx43) is the major connexin protein in ventricular cardiomyocytes.
Six Cx43 proteins assemble into so-called hemichannels at the sarcolemma and opposing …

Diabetes mellitus affects the heart through various mechanisms such as microvascular
defects, metabolic abnormalities, autonomic dysfunction and incompatible immune …

Diabetes is a chronic metabolic disease characterized by hyperglycemia in the absence of
treatment. Among the diabetes-associated complications, cardiovascular disease is the …

Atrial fibrillation (AF) is prevalent in diabetes mellitus (DM); however, the basis for this is
unknown. This study investigated AF susceptibility and atrial electrophysiology in type 1 …

Diabetic cardiomyopathy is defined as the myocardial dysfunction that suffers patients with
diabetes mellitus (DM) in the absence of hypertension and structural heart diseases such as …

Aims Diabetic hyperglycaemia is associated with increased arrhythmia risk. We aimed to
investigate whether hyperglycaemia alone can be accountable for arrhythmias or whether it …