A domino green method for the rapid synthesis of novel fused isoquinoline derivatives via Knoevenagel/Michael/cyclization reactions on aqueous media and their photophysical properties

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A domino green method for the rapid synthesis of novel fused isoquinoline derivatives via Knoevenagel/Michael/cyclization reactions on aqueous media and their photophysical properties†

Nandigama Satish Kumar,^a L. Chandrasekhara Rao,^a N. Jagadeesh Babu^b and H. M. Meshram*^a

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* Corresponding authors

^a Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India
E-mail: hmmeshram@yahoo.com
Fax: +91-40-27193275

^b Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India

Abstract

An expedient, eco-friendly and green-protocol has been developed for the synthesis of novel 4-imino-2-aryl-4H-pyrido[2,1-a]isoquinoline-3-carbonitrile derivatives via Knoevenagel/Michael/cyclisation reactions in one pot under catalyst-free conditions on aqueous media. These products exhibited UV-Vis absorption and photoluminescence properties.

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Article information

DOI: https://doi.org/10.1039/C5RA15948B
Article type: Communication
Submitted: 09 Aug 2015
Accepted: 27 Oct 2015
First published: 28 Oct 2015

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RSC Adv., 2015,5, 95539-95544

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