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A bacterial cysteine protease effector protein interferes with photosynthesis to suppress plant innate immune responses

Cell Microbiol. 2012 May;14(5):669-81. doi: 10.1111/j.1462-5822.2012.01749.x. Epub 2012 Feb 15.

Abstract

The bacterial pathogen Pseudomonas syringae pv tomato DC3000 suppresses plant innate immunity with effector proteins injected by a type III secretion system (T3SS). The cysteine protease effector HopN1, which reduces the ability of DC3000 to elicit programmed cell death in non-host tobacco, was found to also suppress the production of defence-associated reactive oxygen species (ROS) and callose when delivered by Pseudomonas fluorescens heterologously expressing a P. syringae T3SS. Purified His(6) -tagged HopN1 was used to identify tomato PsbQ, a member of the oxygen evolving complex of photosystem II (PSII), as an interacting protein. HopN1 localized to chloroplasts and both degraded PsbQ and inhibited PSII activity in chloroplast preparations, whereas a HopN1(D299A) non-catalytic mutant lost these abilities. Gene silencing of NtPsbQ in tobacco compromised ROS production and programmed cell death by DC3000. Our data reveal PsbQ as a contributor to plant immunity responses and a target for pathogen suppression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis
  • Bacterial Proteins / metabolism
  • Cysteine Proteases / metabolism*
  • Host-Pathogen Interactions*
  • Immune Evasion
  • Immunity, Innate
  • Photosynthesis*
  • Photosystem II Protein Complex / metabolism*
  • Plant Diseases / immunology
  • Plant Diseases / microbiology
  • Protein Interaction Mapping
  • Pseudomonas fluorescens / genetics
  • Pseudomonas fluorescens / pathogenicity
  • Pseudomonas syringae / enzymology*
  • Pseudomonas syringae / pathogenicity
  • Reactive Oxygen Species / antagonists & inhibitors
  • Reactive Oxygen Species / metabolism
  • Solanum lycopersicum / immunology
  • Solanum lycopersicum / microbiology*
  • Virulence Factors / metabolism*

Substances

  • Bacterial Proteins
  • Photosystem II Protein Complex
  • Reactive Oxygen Species
  • Virulence Factors
  • Cysteine Proteases