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Spatiotemporal micropatterning of cells on arbitrary substrates

Anal Chem. 2007 Jun 1;79(11):4066-73. doi: 10.1021/ac062371p. Epub 2007 Apr 28.

Abstract

This paper presents a readily accessible patterning platform--based upon geometric constraints, discrete cell suspension droplets, and controlled cell settling--that provides both temporal and spatial patterning capabilities. As a demonstration, single-cell (and bead) suspensions as well as multicellular human embryonic stem cell colonies are spatiotemporally patterned onto arbitrary substrates. These substrates include tissue culture surfaces, cell monolayers, protein-coated surfaces, and 3D gel matrices. The generation of soluble factor gradients is also demonstrated. This method is completely passive and does not require external power sources. Spatiotemporal patterning provides a foundation for future biological studies that explore the time-dependent relationships between cell-cell signaling and cellular responses.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cell Culture Techniques / instrumentation*
  • Cell Culture Techniques / methods*
  • Humans
  • Mice
  • Polystyrenes
  • Substrate Specificity
  • Time Factors

Substances

  • Polystyrenes