Abstract
In the framework of the preclinical validation of the hypoxic tracer [(18)F]EF3, a comparison was performed between uptake of [(18)F]EF3 and EF5 adducts detected by immunofluorescence in MCa-4, FSA, FSAII, Sa-NH and NFSA tumour-bearing mice. Mice were allowed to breath carbogen (5% CO(2), 95% O(2)), 21% oxygen or 10% oxygen. A significant correlation (r (2)=0.57; p<0.01) was found between the [(18)F]EF3 tumour-to-muscle ratio and the fluorescence intensity of EF5.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Cell Hypoxia
-
Drug Evaluation, Preclinical
-
Etanidazole / analogs & derivatives*
-
Etanidazole / metabolism
-
Fibrosarcoma / diagnostic imaging*
-
Fibrosarcoma / metabolism*
-
Fluorescent Antibody Technique
-
Hydrocarbons, Fluorinated / metabolism*
-
Male
-
Mammary Neoplasms, Experimental / diagnostic imaging*
-
Mammary Neoplasms, Experimental / metabolism*
-
Metabolic Clearance Rate
-
Mice
-
Mice, Inbred C3H
-
Nitroimidazoles / pharmacokinetics*
-
Organ Specificity
-
Oxygen / metabolism*
-
Radionuclide Imaging
-
Radiopharmaceuticals / pharmacokinetics
-
Tissue Distribution
Substances
-
2-(2-nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide
-
Hydrocarbons, Fluorinated
-
Nitroimidazoles
-
Radiopharmaceuticals
-
Etanidazole
-
2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide
-
Oxygen