Abstract
From the latex of Jatropha curcas L. (Euphorbiaceae) a novel cyclic octapeptide was isolated, which we named curcacycline A. The compound was found to contain one threonine, one valine, two glycine, and four leucine residues. By two-dimensional 1H-NMR spectroscopy (HOHAHA and ROESY), its sequence was determined to be Gly1-Leu2-Leu3-Gly4-Thr5-Val6-Leu7-Leu8-Gly1+ ++. Curcacycline A displays a moderate inhibition of (i) classical pathway activity of human complement and (ii) proliferation of human T-cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Cell Division / drug effects
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Complement Pathway, Classical / drug effects
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Humans
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Latex / chemistry
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Sequence Data
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification*
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Peptides, Cyclic / pharmacology
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Plant Proteins / chemistry
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Plant Proteins / isolation & purification*
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Plant Proteins / pharmacology
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Plants, Medicinal / chemistry*
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T-Lymphocytes / cytology
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T-Lymphocytes / drug effects
Substances
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Latex
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Peptides, Cyclic
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Plant Proteins
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curcacyline A