Loenarz C - Search Results

1

Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.

Hillringhaus L, Yue WW, Rose NR, Ng SS, Gileadi C, Loenarz C, Bello SH, Bray JE, Schofield CJ, Oppermann U. Hillringhaus L, et al. Among authors: loenarz c. J Biol Chem. 2011 Dec 2;286(48):41616-41625. doi: 10.1074/jbc.M111.283689. Epub 2011 Sep 13. J Biol Chem. 2011. PMID: 21914792 Free PMC article.

2

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.

Yue WW, Hozjan V, Ge W, Loenarz C, Cooper CD, Schofield CJ, Kavanagh KL, Oppermann U, McDonough MA. Yue WW, et al. Among authors: loenarz c. FEBS Lett. 2010 Feb 19;584(4):825-30. doi: 10.1016/j.febslet.2009.12.055. Epub 2010 Jan 12. FEBS Lett. 2010. PMID: 20067792 Free article.

3

Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.

Thalhammer A, Mecinović J, Loenarz C, Tumber A, Rose NR, Heightman TD, Schofield CJ. Thalhammer A, et al. Among authors: loenarz c. Org Biomol Chem. 2011 Jan 7;9(1):127-35. doi: 10.1039/c0ob00592d. Epub 2010 Nov 15. Org Biomol Chem. 2011. PMID: 21076780 Free PMC article.

4

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.

Flashman E, Bagg EA, Chowdhury R, Mecinović J, Loenarz C, McDonough MA, Hewitson KS, Schofield CJ. Flashman E, et al. Among authors: loenarz c. J Biol Chem. 2008 Feb 15;283(7):3808-15. doi: 10.1074/jbc.M707411200. Epub 2007 Dec 5. J Biol Chem. 2008. PMID: 18063574 Free article.

5

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.

Pollard PJ, Loenarz C, Mole DR, McDonough MA, Gleadle JM, Schofield CJ, Ratcliffe PJ. Pollard PJ, et al. Among authors: loenarz c. Biochem J. 2008 Dec 15;416(3):387-94. doi: 10.1042/BJ20081238. Biochem J. 2008. PMID: 18713068

6

Oxygenase catalyzed 5-methylcytosine hydroxylation.

Loenarz C, Schofield CJ. Loenarz C, et al. Chem Biol. 2009 Jun 26;16(6):580-3. doi: 10.1016/j.chembiol.2009.06.002. Chem Biol. 2009. PMID: 19549596

7

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.

Mecinović J, Loenarz C, Chowdhury R, Schofield CJ. Mecinović J, et al. Among authors: loenarz c. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6192-5. doi: 10.1016/j.bmcl.2009.09.005. Epub 2009 Sep 6. Bioorg Med Chem Lett. 2009. PMID: 19775891

8

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase.

Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CD, Klose RJ, Ratcliffe PJ, Schofield CJ. Loenarz C, et al. Hum Mol Genet. 2010 Jan 15;19(2):217-22. doi: 10.1093/hmg/ddp480. Epub 2009 Oct 19. Hum Mol Genet. 2010. PMID: 19843542 Free PMC article.

9

Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1alpha.

Illingworth CJ, Loenarz C, Schofield CJ, Domene C. Illingworth CJ, et al. Among authors: loenarz c. Biochemistry. 2010 Aug 17;49(32):6936-44. doi: 10.1021/bi100358t. Biochemistry. 2010. PMID: 20695530

10

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases.

Loenarz C, Schofield CJ. Loenarz C, et al. Trends Biochem Sci. 2011 Jan;36(1):7-18. doi: 10.1016/j.tibs.2010.07.002. Epub 2010 Aug 20. Trends Biochem Sci. 2011. PMID: 20728359 Review.

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