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Page 1
Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action.
McFarland JM, Paolella BR, Warren A, Geiger-Schuller K, Shibue T, Rothberg M, Kuksenko O, Colgan WN, Jones A, Chambers E, Dionne D, Bender S, Wolpin BM, Ghandi M, Tirosh I, Rozenblatt-Rosen O, Roth JA, Golub TR, Regev A, Aguirre AJ, Vazquez F, Tsherniak A. McFarland JM, et al. Among authors: colgan wn. Nat Commun. 2020 Aug 27;11(1):4296. doi: 10.1038/s41467-020-17440-w. Nat Commun. 2020. PMID: 32855387 Free PMC article.
Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer.
Bondeson DP, Paolella BR, Asfaw A, Rothberg MV, Skipper TA, Langan C, Mesa G, Gonzalez A, Surface LE, Ito K, Kazachkova M, Colgan WN, Warren A, Dempster JM, Krill-Burger JM, Ericsson M, Tang AA, Fung I, Chambers ES, Abdusamad M, Dumont N, Doench JG, Piccioni F, Root DE, Boehm J, Hahn WC, Mannstadt M, McFarland JM, Vazquez F, Golub TR. Bondeson DP, et al. Among authors: colgan wn. Nat Cancer. 2022 Jun;3(6):681-695. doi: 10.1038/s43018-022-00360-7. Epub 2022 Apr 18. Nat Cancer. 2022. PMID: 35437317 Free PMC article.
Cycling cancer persister cells arise from lineages with distinct programs.
Oren Y, Tsabar M, Cuoco MS, Amir-Zilberstein L, Cabanos HF, Hütter JC, Hu B, Thakore PI, Tabaka M, Fulco CP, Colgan W, Cuevas BM, Hurvitz SA, Slamon DJ, Deik A, Pierce KA, Clish C, Hata AN, Zaganjor E, Lahav G, Politi K, Brugge JS, Regev A. Oren Y, et al. Nature. 2021 Aug;596(7873):576-582. doi: 10.1038/s41586-021-03796-6. Epub 2021 Aug 11. Nature. 2021. PMID: 34381210 Free PMC article.
Variable levels of drift in tunicate cardiopharyngeal gene regulatory elements.
Colgan W, Leanza A, Hwang A, DeBiasse MB, Llosa I, Rodrigues D, Adhikari H, Barreto Corona G, Bock S, Carillo-Perez A, Currie M, Darkoa-Larbi S, Dellal D, Gutow H, Hokama P, Kibby E, Linhart N, Moody S, Naganuma A, Nguyen D, Stanton R, Stark S, Tumey C, Velleca A, Ryan JF, Davidson B. Colgan W, et al. Evodevo. 2019 Oct 11;10:24. doi: 10.1186/s13227-019-0137-2. eCollection 2019. Evodevo. 2019. PMID: 31632631 Free PMC article.
Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis.
Jones MG, Sun D, Min KHJ, Colgan WN, Tian L, Weir JA, Chen VZ, Koblan LW, Yost KE, Mathey-Andrews N, Russell AJC, Stickels RR, Balderrama KS, Rideout WM 3rd, Chang HY, Jacks T, Chen F, Weissman JS, Yosef N, Yang D. Jones MG, et al. Among authors: colgan wn. bioRxiv [Preprint]. 2024 Oct 24:2024.10.21.619529. doi: 10.1101/2024.10.21.619529. bioRxiv. 2024. PMID: 39484491 Free PMC article. Preprint.