Lomefloxacino


Lomefloxacino Aviso médico
Nome IUPAC (sistemática)
(RS)-1-Ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid
Identificadores
CAS	98079-51-7
ATC	J01MA07
PubChem	3948
DrugBank	DB00978
ChemSpider	3811
Informação química
Fórmula molecular	C₁₇H₁₉N₃F₂O₃
Massa molar	351.354 g/mol
SMILES	Fc1c(c(F)c2c(c1)C(=O)C(\C(=O)O)=C/N2CC)N3CC(NCC3)C
Farmacocinética
Biodisponibilidade	?
Metabolismo	?
Meia-vida	6-7 horas
Excreção	?
Considerações terapêuticas
Administração	oral
DL₅₀	?

Lomefloxacino é um fármaco antibiótico do grupo das fluoroquinolonas.^[1]

Uso clínico

O lomefloxacino é utilizado no tratamento das infeções renais e das vias urinárias,^[2]^[3]^[4] das infeções da próstata^[5]^[6]^[7] e das vias respiratórias^[8]^[9]^[10]^[11]^[12].

Referências

↑ P.R.Vademécum
↑ Pisani, E.; R. Bartoletti; A. Trinchieri; M. Rizzo (1996). «Lomefloxacin versus ciprofloxacin in the treatment of complicated urinary tract infections: a multicenter study.». J Chemother. 8 (3): 210-3. PMID 8808718
↑ Klimberg, IW.; CE. Cox; CL. Fowler; W. King; SS. Kim; S. Callery-D'Amico (1998). «A controlled trial of levofloxacin and lomefloxacin in the treatment of complicated urinary tract infection.». Urology. 51 (4): 610-5. PMID 9586615
↑ Guibert, J.; H. Herman; MH. Capron (1997). «[Treatment of uncomplicated recurrent cystitis in women: lomefloxacin versus norfloxacin].». Contracept Fertil Sex. 25 (1): 79-84. PMID 9064058
↑ Andriole, VT. (1991). «Use of quinolones in treatment of prostatitis and lower urinary tract infections.». Eur J Clin Microbiol Infect Dis. 10 (4): 342-50. PMID 1864295
↑ Naber, KG. (2002). «Lomefloxacin versus ciprofloxacin in the treatment of chronic bacterial prostatitis.». Int J Antimicrob Agents. 20 (1): 18-27. PMID 12127707
↑ Costa, FJ. (1994). «Lomefloxacin prophylaxis in visual laser ablation of the prostate.». Urology. 44 (6): 933-6. PMID 7527170
↑ Melani, AS.; M. Pirrelli; F. Sarlo; V. Cantoni (2001). «Safety and effectiveness of lomefloxacin in patients with acute exacerbation of chronic bronchitis (AECB) chronically treated with oral theophyllines.». J Chemother. 13 (6): 628-34. PMID 11806624
↑ Fedoseev, GB.; AV. Emel'ianov; KA. Rudinskiĭ; SE. Shevelev; AV. Bykova. «[Efficacy of lomefloxacin in treatment of patients with chronic bronchitis].». Antibiot Khimioter. 43 (10): 24-6. PMID 9825106
↑ Grassi, C.; C. Albera; E. Pozzi (1992). «Lomefloxacin versus amoxicillin in the treatment of acute exacerbations of chronic bronchitis: an Italian multicenter study.». Am J Med. 92 (4A): 103S-107S. PMID 1316058
↑ Belousov, IuB.; OV. Efremenkova; AV. Sokolov; IF. Tishenkova (1999). «[The importance of fluoroquinolones in treating pneumonia in the elderly].». Antibiot Khimioter. 44 (12): 23-6. PMID 10687030
↑ Kohno, S.; K. Yamaguchi; Y. Dohtsu; H. Koga; T. Hayashi; M. Hirota; A. Saito; K. Hara (1988). «Efficacy of NY-198 against experimental Legionnaires disease.». Antimicrob Agents Chemother. 32 (9): 1427-9. PMID 3196003

[1] P.R.Vademécum

[pmid8808718-2] Pisani, E.; R. Bartoletti; A. Trinchieri; M. Rizzo (1996). «Lomefloxacin versus ciprofloxacin in the treatment of complicated urinary tract infections: a multicenter study.». J Chemother. 8 (3): 210-3. PMID 8808718

[pmid9586615-3] Klimberg, IW.; CE. Cox; CL. Fowler; W. King; SS. Kim; S. Callery-D'Amico (1998). «A controlled trial of levofloxacin and lomefloxacin in the treatment of complicated urinary tract infection.». Urology. 51 (4): 610-5. PMID 9586615

[pmid9064058-4] Guibert, J.; H. Herman; MH. Capron (1997). «[Treatment of uncomplicated recurrent cystitis in women: lomefloxacin versus norfloxacin].». Contracept Fertil Sex. 25 (1): 79-84. PMID 9064058

[pmid1864295-5] Andriole, VT. (1991). «Use of quinolones in treatment of prostatitis and lower urinary tract infections.». Eur J Clin Microbiol Infect Dis. 10 (4): 342-50. PMID 1864295

[pmid12127707-6] Naber, KG. (2002). «Lomefloxacin versus ciprofloxacin in the treatment of chronic bacterial prostatitis.». Int J Antimicrob Agents. 20 (1): 18-27. PMID 12127707

[pmid7527170-7] Costa, FJ. (1994). «Lomefloxacin prophylaxis in visual laser ablation of the prostate.». Urology. 44 (6): 933-6. PMID 7527170

[pmid11806624-8] Melani, AS.; M. Pirrelli; F. Sarlo; V. Cantoni (2001). «Safety and effectiveness of lomefloxacin in patients with acute exacerbation of chronic bronchitis (AECB) chronically treated with oral theophyllines.». J Chemother. 13 (6): 628-34. PMID 11806624

[pmid9825106-9] Fedoseev, GB.; AV. Emel'ianov; KA. Rudinskiĭ; SE. Shevelev; AV. Bykova. «[Efficacy of lomefloxacin in treatment of patients with chronic bronchitis].». Antibiot Khimioter. 43 (10): 24-6. PMID 9825106

[pmid1316058-10] Grassi, C.; C. Albera; E. Pozzi (1992). «Lomefloxacin versus amoxicillin in the treatment of acute exacerbations of chronic bronchitis: an Italian multicenter study.». Am J Med. 92 (4A): 103S-107S. PMID 1316058

[pmid10687030-11] Belousov, IuB.; OV. Efremenkova; AV. Sokolov; IF. Tishenkova (1999). «[The importance of fluoroquinolones in treating pneumonia in the elderly].». Antibiot Khimioter. 44 (12): 23-6. PMID 10687030

[pmid3196003-12] Kohno, S.; K. Yamaguchi; Y. Dohtsu; H. Koga; T. Hayashi; M. Hirota; A. Saito; K. Hara (1988). «Efficacy of NY-198 against experimental Legionnaires disease.». Antimicrob Agents Chemother. 32 (9): 1427-9. PMID 3196003

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