Table 1. Neuron morphology resources currently available for the adult D. melanogaster brain.
| Dataset | Type | Count | Citations |
|---|---|---|---|
| FlyCircuit | Single neuron morphologies stochastically labeled from dense transmitter-related lines | ~23,000 neurons | (Chiang et al., 2011; Shih et al., 2015) |
| FlyLight GMR collection | Collection of genetic driver lines, driven by orthogonal transcription factors GAL4 (Brand and Perrimon, 1993) or (Lai and Lee, 2006) LexA | ~3500 GAL4 lines ~1500 LexA lines |
(Jenett et al., 2012; Pfeiffer et al., 2008) |
| Vienna Tiles collection | Collection of genetic driver lines, driven by orthogonal transcription factors GAL4 or LexA | ~8000 GAL4 lines ~3000 LexA lines |
(Kvon et al., 2014; Tirian and Dickson, 2017) |
| FlyLight split-GAL4 collection | Genetic driver lines labelling small constellations of neurons using the split-GAL4 system | ~400 sparse lines covering the mushroom body, lobula plate and columns, visual projection neurons, ellipsoid body, descending neurons, central complex, olfactory projection neurons (Y. Aso, personal communication, 2019) and lateral horn. | (Aso et al., 2014; Aso and Rubin, 2016; Dolan et al., 2019; Klapoetke et al., 2017; Namiki et al., 2018; Robie et al., 2017; Wolff and Rubin, 2018; Wu et al., 2016) |
| K. Ito, T. Lee and V. Hartenstein | Neuroblast clones for the central brain larval-born neurons, generated using the MARCM method (Lee and Luo, 2001) | ~100 neuroblast clones | (Ito et al., 2013; Wong et al., 2013; Yu et al., 2013) |
| FlyEM and Harvard Medical School | Volume-restricted connectomes | Hundreds of neurons from the mushroom body alpha lobe, two antennal lobe glomeruli and several columns of the optic medulla | (Horne et al., 2018; Takemura et al., 2015, Takemura et al., 2013, Takemura et al., 2017; Tobin et al., 2017) |
| FAFB project | Serial section transmission electron microscopy data for a single, whole adult female fly brain (Zheng et al., 2018), that has a partial automatic segmentation available (Li et al., 2019) | Raw image data for ~ 150,000 neurons of which several hundred have been partially reconstructed in recent publications, 7 thousand more unpublished; anestimated ~ 5% of neurons have some level of reconstruction. | (Dolan et al., 2019; Dolan et al., 2018b; Felsenberg et al., 2018; Frechter et al., 2019; Huoviala et al., 2018; Sayin et al., 2019; Zheng et al., 2018) |
| Various laboratories | Single neuron morphologies extracted from dye-filling (e.g. with biocytin) neurons | Hundreds across a range of studies, some cited here | (Frechter et al., 2019; Grosjean et al., 2011; Jeanne et al., 2018; Jefferis et al., 2007) |