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. 2020 Nov 27;133(22):jcs247957. doi: 10.1242/jcs.247957

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© 2020. Published by The Company of Biologists Ltd

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Fig. 1. — Glucose but not glutamine is a major carbon source for TCA cycle metabolites during early human macrophage activation. (A) Diagram of uniformly labelled [U-¹³C]-glucose catabolism, highlighting the TCA cycle metabolites and their expected glucose-derived ¹³C atoms (filled circles). (B,C) Glucose-derived and M+0 metabolites measured by LC-MS in control and LPS (8 h; 100 ng/ml)-stimulated hMDMs; n=6 donors. See Fig. S1 for individual data points. Glu, glutamate; Succ, succinate. (D) Diagram of uniformly labelled [U-¹³C]-glutamine catabolism, highlighting the TCA cycle metabolites and their expected glutamine-derived ¹³C atoms (filled circles). (E,F) Glutamine-derived and M+0 metabolites measured by LC-MS in control and LPS (8 h; 100 ng/ml)-stimulated hMDMs; n=6 donors. See Fig. S1 for individual data points.