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. Author manuscript; available in PMC: 2014 Sep 20.
Published in final edited form as: J Comput Aided Mol Des. 2010 Sep 30;24(11):943–956. doi: 10.1007/s10822-010-9386-9

Fig. 6.

Fig. 6

Transient transfection assays to determine the activity of SHP mutants in inhibiting HNF4a transactivation of the ApoCIII promoter luciferase reporter. Luc activities were determined and normalized to β-gal activities. Data are expressed as means ± SD (*p<0.01 vs. gray bar-HNF4a; p<0.01 vs. white bar-SHPwt). Each SHP mutant construct was generated using site directed mutagenesis, which was confirmed by sequencing